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Catalog Products » Recombinant Proteins » Cytokines » Interleukin-17 Receptor D (IL-17 RD), Mouse

IL-17 RD, Mouse

Synonyms IL17RLM; SEF
Description Interleukin-17 receptor D (IL-17RD) , also known as similar expression to the fibroblast growth factor receptor (SEF), is a member of the interleukin-17 receptor family. Studies indicate that IL-17RD interacts with IL-17R to facilitate IL-17 signaling. Additionally, IL-17RD may play an important role in preventing certain types of cancer. Studies suggest that IL-17D acts as a feedback inhibitor of fibroblast growth factor-mediated MAPK signaling and ERK activation. Studies indicate that IL-17D can bind to MEK/ERK complexes preventing nuclear ERK translocation and subsequent cell proliferation.
Recombinant Mouse IL-17 RD produced in CHO cells is a polypeptide chain containing 271 amino acids. A fully biologically active molecule, rmIL-17 RD has a molecular mass of 53-56 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques at GenScript.
Accession No Q8JZL1-1
Source CHO
Specific Activity ED50 < 5 μg /ml, measured in a cell proliferation assay using wt MEF cells.
Sequence
GSGRARGADT CGWRGVGPAS RNSGLHNITF RYDNCTTYLN
PGGKHAIADA QNITISQYAC HDQVAVTILWSPGALGIEFL KGFRVILEEL
KSEGRQCQQL ILKDPKQLNS SFRRTGMESQ PFLNMKFETD
YFVKIVPFPSIKNESNYHPF FFRTRACDLL LQPDNLACKP FWKPRNLNIS
QHGSDMHVSF DHAPQNFGFR GFHVLYKLKHEGPFRRRTCR QDQNTETTSC
LLQNVSPGDY IIELVDDSNT TRKAAQYVVK SVQSPWAGPI
R

Measured Molecular Weight 53-56 kDa, observed by reducing SDS-PAGE.
Purity > 95% as analyzed by SDS-PAGE&HPLC.
Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution Reconstituted in ddH2O or PBS at 100 μg/ml.
Endotoxin Level < 0.2 EU/μg, determined by LAL method.
Storage Lyophilized recombinant Mouse Interleukin-17 D Receptor remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, Mouse Interleukin-17 D Receptor should be stable up to 1 week at 4°C or up to 2 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles.
Note For research use only




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Cat. No. Z03328
Size
Price
50 ug $145.00
10 ug $59.00
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