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Catalog Products » Recombinant Proteins » Growth Factors » Protransforming Growth Factor-alpha (TGF-α), Human

TGF-α, Human

Synonyms Human TGF-α,Human TGF-type I
Description Transforming Growth Factor-alpha (TGF-α) , also known as sarcoma growth factor, TGF-type I and ETGF, is a member of the EGF family of cytokines. It is expressed in monocytes, brain cells, keratinocytes and various tumor cells. TGF-α signals through EGFR and acts synergistically with TGF-beta to promote the proliferation of a wide range of epidermal and epithelial cells. TGF-α is a transforming growth factor that is a ligand for the epidermal growth factor receptor, which activates a signaling pathway for cell proliferation, differentiation and development. This protein may act as either a transmembrane-bound ligand or a soluble ligand. The biological actions of TGF-α and EGF are similar. For instance, TGF-α and EGF bind to the same receptor. When TGF-α binds to EGFR it can initiate multiple cell proliferation events.
Recombinant Human TGF-α produced in E. coli cells is a single non-glycosylated polypeptide chain containing 50 amino acids. A fully biologically active molecule, rhTGF-α has a molecular mass of 5.8 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques at GenScript.
Accession No P02775
Source E. coli
Biological Activity ED50 < 0.2ng/ml, measured by Cell Proliferation Assay using BALB/c 3T3 cells, corresponding to a specific activity of ≥ 5 x 106 units/mg.
Sequence
VVSHFNDCPD SHTQFCFHGT CRFLVQEDKP ACVCHSGYVG
ARCEHADLLA

Measured Molecular Weight 5.8 kDa, observed by reducing SDS-PAGE
Purity > 95% as analyzed by SDS-PAGE
Formulation Lyophilized after extensive dialysis against PBS.
Reconstitution Reconstituted in ddH2O or PBS at 100 μg/ml.
Endotoxin Level < 0.2 EU/μg, determined by LAL method.
Storage Lyophilized recombinant Human TGF-α remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, Human TGF-α should be stable up to 1 week at 4°C or up to 3 months at -20°C.
Note For research use only




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Cat. No. Z03332
Size
Price
10 ug $29.00
50 ug $59.00
1 mg $550.00