Kallikrein 1, Human

*This product has been discontinued!*

Kallikrein 1 (KLK1), also known as tissue kallikrein, is a member of the human tissue kallikrein family. Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis, and some have the potential to be used as cancer and other disease biomarkers. Human KLK1 precursor contains a signal peptide (residues 1 to 18), a short pro peptide (residues 19 to 24) and a mature chain (residues 25 to 262).Recombinant Human Kallikrein 1 produced in CHO cells is a polypeptide chain containing 292 amino acids. A fully biologically active molecule, rhKLK1 has a molecular mass of 46 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques at GenScript.

Cat. No.	Z03363
Size	Buy in bulk

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Product Introduction Background

Product Introduction

Purity	> 95% as analyzed by SDS-PAGE.
Endotoxin Level	< 0.2 EU/μg, determined by LAL method.
Formulation	Liquid after a 0.2 μm filtered solution in 25 mM Tris-HCl, 75 mM NaCl,pH8.0.

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Background

Target Background

Kallikrein 1 (KLK1), also known as tissue kallikrein, is a member of the human tissue kallikrein family. Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis, and some have the potential to be used as cancer and other disease biomarkers. Human KLK1 precursor contains a signal peptide (residues 1 to 18), a short pro peptide (residues 19 to 24) and a mature chain (residues 25 to 262).
Recombinant Human Kallikrein 1 produced in CHO cells is a polypeptide chain containing 292 amino acids. A fully biologically active molecule, rhKLK1 has a molecular mass of 46 kDa analyzed by reducing SDS-PAGE and is obtained by chromatographic techniques at GenScript.

Synonyms

KLK1

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