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Catalog Products » Recombinant Proteins » Growth Factors » GDNF, Human

GDNF, Human

Synonyms Glial-Derived Neurotrophic Factor, ATF-1; ATF2; HFB1-GDNF; HSCR3
Description Glial cell line-derived neurotrophic factor (GDNF) is a neurotrophic factor belonging to the TGF-beta super family and is necessary for neuron survival and phenotypic maintenance in the central and peripheral nervous systems. G-DNF has the potential to support the differentiation and survival of many neuron subpopulations, especially dopaminergic neurons and motor neurons, as well as Purkinje cells and sympathetic neurons. Sertoli cells, type 1 astrocytes, Schwann cells, neurons, pinealocytes and skeletal muscle cells are known to express GDNF in human. GDNF has been shown to interact with GFRA2 and GDNF family receptor alpha 1. Mutations in this gene may be associated with Hirschsprung's disease, Parkinson's disease and amyotrophic lateral sclerosis (ALS).
The recombinant human G-DNF expressed in E.coli is a disulfide-linked homo-dimer, with an apparent molecular weight of 17 kDa.
Accession No P39905
Source E.coli
Biological Activity ED50<5 µg/ml, measured in a proliferation assay using C6 cells.
Sequence
MSPDKQMA VLPRRERN RQAAAANP ENSRGKGR RGQRGKNR
GCVLTAIH LNVTDLGL GYETKEEL IFRYCSGS CDAAETTY
DKILKNLS RNRRLVSD KVGQACCR PIAFDDDL SFLDDNLV
YHILRKHS AKRCGCI

Measured Molecular Weight 17 kDa, observed by reducing SDS-PAGE.
Purity > 95% as analyzed by SDS-PAGE.
Formulation Lyophilized after extensive dialysis against PBS.
Reconstitution Reconstituted in ddH2O or PBS at 100 μg/ml.
Endotoxin Level <0.2 EU/μg, determined by LAL method.
Storage Lyophilized recombinant Human GDNF remains stable up to 6 months when stored at lower than -70°C from date of receipt. Upon reconstitution, Human GDNF should be stable up to 1 week at 4°C or up to 3 months at -20°C.




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Cat. No. Z03387
Size
Price
10 μg $85.00
50 μg $275.00
1 mg $2100.00