Catalog Products » Recombinant Proteins » B7-H2/ICOSLG, His, Human

B7-H2/ICOSLG His, Human

*This product has been discontinued!*
B7-H2, best known as the ligand of inducible costimulator, belongs to B7-CD28 family, is a transmembrane glycoprotein of approximately 60 kDa. B7-H2 is expressed on antigen presenting cells such as B cells, macrophages, dendritic cells, and also in monocytes, and is a ligand for CD28 and CTLA-4 in human, whereas these interactions are not conserved in mouse. B7-H2 and B7-1 or B7-2 interacted with CD28 through distinctive domains. B7-H2-CD28 interaction is essential for the costimulation of human T cells' primary responses to allogeneic antigens and memory recall responses.
Z03415
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Product Introduction
Species Human
Protein Construction
B7-H2/ICOSLG (Asp19-Ser258)
Accession # O75144
Poly-His
N-term C-term
Purity > 95% as analyzed by SDS-PAGE
Endotoxin Level < 0.2 EU/μg of protein by gel clotting method
Biological Activity Immobilized B7-H2/ICOSLG His, Human at 1.0 μg/ml (100 µl/well) can bind ICOS Fc Chimera, Human(Cat. No.: Z03412).
Expression System HEK 293
Apparent Molecular Weight 45~55 kDa, on SDS-PAGE under reducing conditions.
Formulation Lyophilized from a 0.2 μm filtered solution in PBS, 5% trehalose and mannitol.
Reconstitution It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH₂O or PBS up to 100 μg/ml.
Storage & Stability Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles.

Background
Target Background B7-H2, best known as the ligand of inducible costimulator, belongs to B7-CD28 family, is a transmembrane glycoprotein of approximately 60 kDa. B7-H2 is expressed on antigen presenting cells such as B cells, macrophages, dendritic cells, and also in monocytes, and is a ligand for CD28 and CTLA-4 in human, whereas these interactions are not conserved in mouse. B7-H2 and B7-1 or B7-2 interacted with CD28 through distinctive domains. B7-H2-CD28 interaction is essential for the costimulation of human T cells' primary responses to allogeneic antigens and memory recall responses.
Synonyms ICOSLG; B7-H2; B7H2; B7RP-1; B7RP1; CD275; GL50; ICOS-L; ICOSL; LICOS; ICOS ligand

For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.


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