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Catalog Products » VISTA/B7-H5, His, Human

VISTA/B7-H5, His, Human

Synonyms VSIR; B7-H5; B7H5; GI24; PP2135; SISP1; DD1alpha; VISTA; C10orf54; chromosome 10 open reading frame 54; PD-1H; V-set immunoregulatory receptor; Dies1
Description V-domain Ig suppressor of T cell activation (VISTA), also known as B7-H5, is a type I transmembrane protein that functions as an immune checkpoint. VISTA belongs to the immunoglobulin superfamily and has one IgV domain. It is primarily expressed in white blood cells and its transcription is partially controlled by p53. VISTA can act as both a ligand and a receptor on T cells to inhibit T cell effector function and maintain peripheral tolerance. VISTA may also promote differentiation of embryonic stem cells by inhibiting BMP4 signaling (By similarity) and may stimulate MMP14-mediated MMP2 activation.
Accession No Q9H7M9
Species Human
Source HEK293
Tag C-terminal 6×His

Molecular Weight ~33.9KDa, on SDS-PAGE under reducing conditions
Purity > 90% as analyzed by SDS-PAGE
Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution Reconstitute the lyophilized powder in ddH2O or PBS up to 100 μg/ml.
Endotoxin Level < 1 EU/μg of protein by gel clotting method
Storage Upon receiving, lyophilized recombinant CD24 remains stable up to 6 months at lower than -70 °C. Upon reconstitution, CD24 should be stable up to 1 week at 4 °C or up to 3 months at -20 °C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles.
Note For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.

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Cat. No. Z03428
Size Price
100 μg $200.00
1 mg $1200.00