|Synonyms||VSIR; B7-H5; B7H5; GI24; PP2135; SISP1; DD1alpha; VISTA; C10orf54; chromosome 10 open reading frame 54; PD-1H; V-set immunoregulatory receptor; Dies1|
|Description||V-domain Ig suppressor of T cell
activation (VISTA), also known as B7-H5, is a type I transmembrane protein that
functions as an immune checkpoint. VISTA belongs to the immunoglobulin
superfamily and has one IgV domain. It is primarily expressed in white blood
cells and its transcription is partially controlled by p53. VISTA can act as
both a ligand and a receptor on T cells to inhibit T cell effector function and
maintain peripheral tolerance. VISTA may also promote differentiation of
embryonic stem cells by inhibiting BMP4 signaling (By similarity) and may
stimulate MMP14-mediated MMP2 activation.
|Molecular Weight||~33.9KDa, on SDS-PAGE
under reducing conditions
|Purity||> 90% as analyzed by SDS-PAGE
|Formulation|| Lyophilized from a 0.2 μm filtered
solution in PBS.
the lyophilized powder in ddH2O or PBS up to 100 μg/ml.
|Endotoxin Level||< 1 EU/μg of protein by gel
|Storage||Upon receiving, lyophilized recombinant CD24 remains stable up to 6 months at lower than -70 °C. Upon reconstitution, CD24 should be stable up to 1 week at 4 °C or up to 3 months at -20 °C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles.|
|Note||For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.|
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