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DNAM-1/CD226, His, Human

CD226 (Cluster of Differentiation 226), also known as PTA1 (outdated term, 'platelet and T cell activation antigen 1')[5] or DNAM-1 (DNAX Accessory Molecule-1), is a ~65 kDa glycoprotein expressed on the surface of natural killer cells, platelets, monocytes and a subset of T cells. It is a member of the immunoglobulin superfamily. This protein is involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell. It is the cell surface receptor for NECTIN2 and its main ligands are CD112 and CD155. It stimulates T-cell proliferation and cytokine production, including that of IL-2, IL-5, IL-10, IL-13, and IFNγ upon ligand binding.
$40.00
Z03455-10

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Product Introduction
Species Human
Protein Construction
DNAM-1/CD226 (Glu19-Asn247)
Accession # Q15762		 Poly-His
N-term C-term
Purity > 90% as analyzed by SDS-PAGE
Endotoxin Level < 1 EU/μg of protein by gel clotting method
Biological Activity DNAM-1/CD226, His, Human can bind with CHO-K1/aAPC/CD155 Clone by FACS analysis.
Expression System HEK 293
Apparent Molecular Weight ~39.3 kDa, on SDS-PAGE under reducing conditions.
Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH₂O or PBS up to 100 μg/ml.
Storage & Stability Upon receiving, this product remains stable for 6 months at lower than -70°C. Upon reconstitution, the product should be stable for 1 week at 4°C or for 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles.
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DNAM-1/CD226, His, Human

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DNAM-1/CD226, His, Human

FACS analysis of DNAM-1/CD226, His, Human (Cat. No: Z03455) and CHO-K1/aAPC/CD155 Clone (CHO-K1 cell overexpressing human CD155), compared with blank control (green line, untreated cell) and negative control (blue line, only treated with THE™ His Tag Antibody [iFluor 488], mAb, Mouse (Cat. No. A01800)), DNAM-1/CD226, His, Human can bind with CHO-K1/aAPC/CD155 Clone. »

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Background
Target Background CD226 (Cluster of Differentiation 226), also known as PTA1 (outdated term, 'platelet and T cell activation antigen 1')[5] or DNAM-1 (DNAX Accessory Molecule-1), is a ~65 kDa glycoprotein expressed on the surface of natural killer cells, platelets, monocytes and a subset of T cells. It is a member of the immunoglobulin superfamily. This protein is involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell. It is the cell surface receptor for NECTIN2 and its main ligands are CD112 and CD155. It stimulates T-cell proliferation and cytokine production, including that of IL-2, IL-5, IL-10, IL-13, and IFNγ upon ligand binding.
Synonyms DNAM-1; DNAM1; PTA1; TLiSA1; CD226 molecule
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For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.