GMFB, Human

Glia maturation factor beta (GMFB) contains an ADF-H domain，which is a member of the actin-binding proteins ADF family, GMF subfamily. It is a nerve growth factor implicated in nervous system development, angiogenesis, and immune function. GMFB causes differentiation of brain cells, stimulation of neural regeneration, and inhibition of proliferation of tumor cells. It is phosphorylated after phorbol ester stimulation and is crucial for the nervous system. GMFB overexpression in astrocytes results in the increase of BDNF production. GMFB expression is increased by exercise, thus BDNF is important for exercise-induction of BDNF.

Price	$525.00
Cat. No.	Z03576-100
Size	100 μg 1 mg Buy in bulk
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Product Introduction Background Bottom Notes

Product Introduction

Species

Human

Protein Construction

GMFB (Met1-His142) Accession # P60983	Poly-His
N-term	C-term

Purity

≥ 95% as analyzed by SDS-PAGE

Endotoxin Level

< 1 EU/μg of protein by LAL method

Expression System

E. coli

Apparent Molecular Weight

~18 kDa, on SDS-PAGE under reducing conditions.

Formulation

Lyophilized from a 0.2 μm filtered solution of 20mM Tris-HCl, 200mM NaCl, pH 8.0.

Reconstitution

It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in distilled water up to 100 μg/ml.

Storage & Stability

Upon receiving, this product remains stable for 6 months at -70°C or -20°C. Upon reconstitution, the product should be stable for 1 week at 4-7°C and for 3 months at -20 °C or below. Avoid repeated freeze-thaw cycles.

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Background

Target Background

Synonyms

Glia maturation factor beta; GMF-beta

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For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.