TROP-2/TACSTD2, His, Cynomolgus

Trop-2,also known as epithelial glycoprotein-1 antigen (EGP-1),is a protein that in humans is encoded by the TACSTD2 gene.Mutations of this gene result in gelatinous drop-like corneal dystrophy, an autosomal recessive disorder characterized by severe corneal amyloidosis leading to blindness.

Price	$205.00
Cat. No.	Z03842-100
Size	100 μg 500 μg Buy in bulk
Quantity
Est. Delivery


Ask us a question

Product Introduction Background Bottom Notes

Product Introduction

Species

Cynomolgus

Protein Construction

TROP-2/TACSTD2 (His27-Thr274) Accession # XP_005543292.1	His
N-term	C-term

Purity

> 90% as determined by Bis-Tris PAGE

Endotoxin Level

Less than 1EU per μg by the LAL method.

Biological Activity

Measured by its binding ability in a functional ELISA.Test result was comparable to standard batch.

Expression System

HEK293

Theoretical Molecular Weight

28.7 kDa

Apparent Molecular Weight

Due to glycosylation, the protein migrates to 40-55 kDa based on Bis-Tris PAGE result.

Formulation

Lyophilized from a 0.22 μm filtered solution in PBS, pH 7.4.

Reconstitution

Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.

Storage & Stability

Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

Back

Immobilized TROP-2/TACSTD2, His, Cynomolgus, His Tag at 0.5 μg/ml (100 μl/well) on the plate. Dose response curve for Anti-TROP-2 Antibody, hFc Tag with the EC50 of 4.4 ng/ml determined by ELISA. »

The purity of TROP-2/TACSTD2, His, Cynomolgus is greater than 95% as determined by SEC-HPLC. »

TROP-2/TACSTD2, His, Cynomolgus on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

Background

Target Background	Trop-2 (Tumor-associated calcium signal transducer 2) is also known as epithelial glycoprotein-1 antigen (EGP-1). It is encoded by the TACSTD2 gene. The mutations of Trop-2 gene cause an autosomal recessive disorder. Trop-2 causes cancer cell growth, proliferation, invasion, migration, and survival of cancer cells
Synonyms	EGP1; EGP-1; TROP2; GA733-1; gp50; T16; TACSTD2; TROP-2; M1S1; TACD2

Back

For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.