Catalog Products » B7-H3/CD276, His, Cynomolgus
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B7-H3/CD276, His, Cynomolgus

B7-H3, a member of the B7 family of immunomodulatory molecules, is overexpressed in a wide range of solid cancers.B7-H3 binds to activated T cells via an as yet unidentified receptor. In assays using sub-optimal amount so anti-CD3 stimulation, 2Ig‑B7‑H3 enhances T cell proliferation, T cell interferon-gamma (IFN-gamma) production, and cytotoxic T cells induction.
$330.00
Z03886-100

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Product Introduction
Species Cynomolgus
Protein Construction
B7-H3/CD276 (Leu29-Glu465)
Accession # XP_015308534.1		 His
N-term C-term
Purity > 95% as determined by Bis-Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA.Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 48.2 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 70-80 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from a 0.22 μm filtered solution in PBS, pH 7.4.
Reconstitution It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH2O more than 100 μg/ml.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
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B7-H3/CD276, His, Cynomolgus

Immobilized B7-H3/CD276, His, Cynomolgus at 1 μg/ml (100 μl/well) on the plate. Dose response curve for Anti-B7-H3 Antibody, hFc Tag with the EC50 of 5.2 ng/ml determined by ELISA. »

B7-H3/CD276, His, Cynomolgus

The purity of B7-H3/CD276, His, Cynomolgus is greater than 95% as determined by SEC-HPLC. »

B7-H3/CD276, His, Cynomolgus

B7-H3/CD276, His, Cynomolgus on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

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Background
Target Background B7-H3, a member of the B7 family of immunomodulatory molecules, is overexpressed in a wide range of solid cancers.B7-H3 binds to activated T cells via an as yet unidentified receptor. In assays using sub-optimal amount so anti-CD3 stimulation, 2Ig‑B7‑H3 enhances T cell proliferation, T cell interferon-gamma (IFN-gamma) production, and cytotoxic T cells induction.
Synonyms B7H3; B7-H3; CD276; PSEC0249; UNQ309; PRO352; B7 homolog 3; CD276
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For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.