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FOLR4/Juno, His, Mouse

Izumo1 is the only essential sperm-egg fusion protein currently known on mammalian sperm, and its egg receptor (Juno; formerly Folr4) was recently discovered. Male knockout mice for Izumo1 and female knockout mice for Juno are both healthy but sterile. Here, both sperm-egg binding proteins are shown to be evolving under positive selection. Juno's presence in mammals alone, suggesting a recent mammalian-specific duplication and neofunctionalization of the ancestral folate receptor.
$370.00
Z06127-100

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Product Introduction
Species Mouse
Protein Construction
FOLR4/Juno (Gly20-Gly222)_x000D_
Accession # Q9EQF4-1		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Expression System HEK293
Theoretical Molecular Weight 24.7 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 35-40 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
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FOLR4/Juno, His, Mouse

The purity of FOLR4/Juno, His, Mouse is greater than 95% as determined by SEC-HPLC. »

FOLR4/Juno, His, Mouse

FOLR4/Juno, His, Mouse on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

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Background
Target Background Izumo1 is the only essential sperm-egg fusion protein currently known on mammalian sperm, and its egg receptor (Juno; formerly Folr4) was recently discovered. Male knockout mice for Izumo1 and female knockout mice for Juno are both healthy but sterile. Here, both sperm-egg binding proteins are shown to be evolving under positive selection. Juno's presence in mammals alone, suggesting a recent mammalian-specific duplication and neofunctionalization of the ancestral folate receptor.
Synonyms Folate receptor 4; FR-delta; FR delta; Izumo1r; Folbp3; Juno; FOLR4, LOC390243
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.