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LAIR1/CD305, His, Mouse

LAIR1 (leukocyte-associated Ig-like receptor-1, designated CD305) is an approximately 40 kDa type I transmembrane inhibitory glycoprotein belonging to the Ig superfamily.LAIR1 functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation.
$250.00
Z06237-100

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Product Introduction
Species Mouse
Protein Construction
LAIR1/CD305 (Gln22-Tyr141)_x000D_
Accession # Q8BG84-1		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Expression System HEK293
Theoretical Molecular Weight 14.6 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 30-42 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
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LAIR1/CD305, His, Mouse

The purity of LAIR1/CD305, His, Mouse is greater than 95% as determined by SEC-HPLC. »

LAIR1/CD305, His, Mouse

LAIR1/CD305, His, Mouse on Bis-Tris PAGE under reduced conditions. The purity is greater than 95%. »

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Background
Target Background LAIR1 (leukocyte-associated Ig-like receptor-1, designated CD305) is an approximately 40 kDa type I transmembrane inhibitory glycoprotein belonging to the Ig superfamily.LAIR1 functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation.
Synonyms CD305; HLAIR1; LAIR1; LAIR-1
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.