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PD-L2/B7-DC, His, Mouse

PD-1 ligand 2 (PD-L2) as a second ligand for PD-1 and compare the function and expression of PD-L1 and PD-L2. Engagement of PD-1 by PD-L2 dramatically inhibits T cell receptor (TCR)-mediated proliferation and cytokine production by CD4 T cells. At low antigen concentrations, PD-L2-PD-1 interactions inhibit strong B7-CD28 signals.
$300.00
Z06303-100

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Product Introduction
Species Mouse
Protein Construction
PD-L2/B7-DC (Leu20-Trp221)_x000D_
Accession # Q9WUL5		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 23.92 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 40-60 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
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PD-L2/B7-DC, His, Mouse

Immobilized PD-L2/B7-DC, His, Mouse, His Tag at 5 μg/ml (100 μI/well) on the plate. Dose response curve for Biotinylated Human PD-1, hFc Tag with the EC50 of 0.34 μg/ml determined by ELISA. »

PD-L2/B7-DC, His, Mouse

The purity of PD-L2/B7-DC, His, Mouse is greater than 95% as determined by SEC-HPLC. »

PD-L2/B7-DC, His, Mouse

PD-L2/B7-DC, His, Mouse on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

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Background
Target Background PD-1 ligand 2 (PD-L2) as a second ligand for PD-1 and compare the function and expression of PD-L1 and PD-L2. Engagement of PD-1 by PD-L2 dramatically inhibits T cell receptor (TCR)-mediated proliferation and cytokine production by CD4 T cells. At low antigen concentrations, PD-L2-PD-1 interactions inhibit strong B7-CD28 signals.
Synonyms PDL2; PD-L2; Butyrophilin B7-DC; CD273, PDCD1 ligand 2; PDCD1L2; PDCD1LG2; B7DC; bA574F11.2; Btdc
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.