TNFSF12/TWEAK, rFc Chimera, Mouse

Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) is a well known multifunctional cytokine extensively distributed in cell types and tissues. Accumulating evidence has shown that TWEAK binding to the receptor factor-inducible 14 (Fn14) participates in diverse pathologic processes including cell proliferation and death, angiogenesis, carcinogenesis and inflammation.

Price	$390.00
Cat. No.	Z06384-100
Size	100 μg 500 μg Buy in bulk
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Product Introduction Background Bottom Notes

Product Introduction

Species

Mouse

Protein Construction

Rabbit Fc	TNFSF12/TWEAK (Ser46-His249)_x000D_ Accession # O54907
N-term	C-term

Purity

> 95% as determined by Bis-Tris PAGE

Endotoxin Level

Less than 1EU per μg by the LAL method.

Biological Activity

Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch.

Expression System

HEK293

Theoretical Molecular Weight

48.95 kDa

Apparent Molecular Weight

Due to furin cleavage and glycosylation, the protein migrates to 40-50 kDa based on Bis-Tris PAGE result.

Formulation

Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4).

Reconstitution

Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.

Storage & Stability

Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

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Immobilized Mouse TNFRSF12A, hFc Tag at 5 μg/ml (100 μl/well) on the plate. Dose response curve for TNFSF12/TWEAK, rFc Chimera, Mouse, Rabbit Fc Tag with the EC50 of 0.28 μg/ml determined by ELISA. »

TNFSF12/TWEAK, rFc Chimera, Mouse on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

TNFSF12/TWEAK, rFc Chimera, Mouse, Rabbit Fc Tag immobilized on CM5 Chip can bind Mouse TNFRSF12A, hFc Tag with an affinity constant of 0.12 nM as determined in SPR assay (Biacore T200). »

Background

Target Background	Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) is a well known multifunctional cytokine extensively distributed in cell types and tissues. Accumulating evidence has shown that TWEAK binding to the receptor factor-inducible 14 (Fn14) participates in diverse pathologic processes including cell proliferation and death, angiogenesis, carcinogenesis and inflammation.
Synonyms	TNFSF12; APO3 ligand; APO3L; DR3LG; UNQ181/PRO207; TWEAK; MGC129581

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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.