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Monocytic microparticles activate endothelial cells in an IL-1βdependent manner.

Blood.. 2011-08;  118(8):2366 - 2374
Jian-Guo Wang, Julie C. Williams, Beckley K. Davis, Ken Jacobson, Claire M. Doerschuk, Jenny P.-Y. Ting, and Nigel Mackman. Division of Hematology and Oncology, Department of Medicine, McAllister Heart Institute, Chapel Hill, NC, USA.
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Microparticles (MPs) are shed from activated and dying cells. They can transmit signals from cell to cell, locally or at a distance through the circulation. Monocytic MPs are elevated in different diseases, including bacterial infections. Here, we investigated how monocytic MPs activate endothelial cells. We found that MPs from lipopolysaccharide (LPS)-treated THP-1 monocytic cells bind to and are internalized by human endothelial cells. MPs from LPS-treated THP-1 cells, but not untreated cells, induced phosphorylation of ERK1/2, activation of the nuclear factor-B pathway and expression of cell adhesion molecules intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and E-selectin. Similar resul... More