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Small Peptide Modulation of Fibroblast Growth Factor Receptor 3-Dependent Postnatal Lymphangiogenesis.

Lymphat Res Biol. 2019; 
PerraultDavid P，LeeGene K，ParkSun Young，LeeSunju，ChoiDongwon，JungEunson，SeongYoung Jin，ParkEun Kyung，SungCynthia，YuRoy，BouzAntoun，PourmoussaAustin，KimSoo Jung，HongYoung-Kwon，WongAl
Products/Services Used Details Operation
Peptide Synthesis … Sources or other reagents used are as follows: 9-cisRA (R4643; Sigma-Aldrich, Inc.) and FGF2 (Sigma). Peptide P3 (VSPPLTLGQLLS) and scrambled peptide (LQVLSTLPSLGP) were synthesized in vitro with guaranteed TFA removal and at a purity >98% (GenScript USA, Inc.) … Get A Quote

Abstract

The fibroblast growth factor receptor (FGFR) family includes transmembrane receptors involved in a wide range of developmental and postdevelopmental biologic processes as well as a wide range of human diseases. In particular， FGFR3 has been implicated in the mechanism by which 9-cis retinoic acid (9-cisRA) induces lymphangiogenesis and improves lymphedema. The purpose of this study was to validate the efficacy of a novel small peptide FGFR3 inhibitor， peptide P3 (VSPPLTLGQLLS)， and to elucidate the role of FGFR3 in 9-cisRA-induced lymphangiogenesis using this peptide.

Keywords

9-cis retinoic acid，FGFR3，VSPPLTLGQLLS，lymphangiogenesis，lymphatic endothelial cell，lymphedema，peptide inhib
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