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Induction of SARS-CoV-2 neutralizing antibodies by CoronaVac and BNT162b2 vaccines in naïve and previously infected individuals

EBioMedicine. 2022-03; 
Nicolás A Muena, Tamara García-Salum, Catalina Pardo-Roa, María José Avendaño, Eileen F Serrano, Jorge Levican, Leonardo I Almonacid, Gonzalo Valenzuela, Estefany Poblete, Shirin Strohmeier, Erick Salinas, Andres Muñoz, Denise Haslwanter, Maria Eugenia Dieterle, Rohit K Jangra, Kartik Chandran, Claudia González, Arnoldo Riquelme, Florian Krammer, Nicole D Tischler, Rafael A Medina
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Proteins, Expression, Isolation and Analysis … SARS-CoV-2 spike or nucleocapsid (GenScript #Z03488) proteins, as previously described. The … We used a convenience sampling approach and included n = 37 outpatients and n = 37 … Get A Quote


background: A major challenge of the SARS-CoV-2 pandemic is to better define "protective thresholds" to guide the global response. We aimed to characterize the longitudinal dynamics of the antibody responses in naturally infected individuals in Chile and compared them to humoral responses induced after immunization with CoronaVac-based on an inactivated whole virus -or the BNT162b2- based on mRNA-vaccines. We also contrasted them with the respective effectiveness and efficacy data available for both vaccines. methods: We determined and compared the longitudinal neutralizing (nAb) and anti-nucleocapsid (anti-N) antibody responses of 74 COVID-19 individuals (37 outpatient and 37 hospitalized) during the acute dis... More


COVID-19, Neutralizing antibody persistence, SARS-CoV-2 vaccines, Serological response, Vaccination boost