This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq, Jul 2008]
The human RET gene is shown in the context of the human genome below. To see information about the RET gene in other species, please use the Search Tool to select your desired species. GenScript has in-stock ORF clones for mouse RET, rat RET, and human RET, as well as on-demand RET ORF clones in 183 other species.
CloneEZ™ ORF CDNA Clones make it easy to order customized expression-ready ORF clones from the world's largest commercial ORF clone database.
