![Targeting inflammatory processes in chronic disease states with GenScript antibody services]( "Targeting inflammatory processes in chronic disease states with GenScript antibody services")
Targeting inflammatory processes in chronic disease states with GenScript antibody services
Dr. Victoria McGilligan is a senior lecturer at Ulster University, School of Medicine. Her team conducts research as part of the Personalised Medicine Centre. The group aims to uncover and characterize relevant inflammatory biomarkers in chronic disease states and develop antibody-drug therapies for various conditions, such as coronary artery disease (CAD) and glaucoma.
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Our research focuses on the development of therapeutic antibodies for chronic inflammatory conditions. We have a keen interest in the NLRP3 inflammasome pathway.
- Victoria McGilligan, Ulster University
Project’s Critical Challenge
Dr McGilligan’s research has focused on targeting the NLRP3 inflammasome using a unique bispecific antibody approach. Results to date are promising, demonstrating the efficacy of the antibody to preserve retinal ganglion cell loss in an animal model of glaucoma (Chemaly et al., 2020). The antibody also has proved efficacious for inhibiting plaque development in an animal model of atherosclerosis (Delfos et al. 2023).
Access to reliable, high-quality antibody development technology is a challenge in furthering the development of antibody therapies for diseases heavily associated with inflammation. Therefore, Dr McGilligan is relying on GenScript’s expertise in high-quality antibody development for project acceleration.
GenScript Partnership Benefit
About the partnership benefits, Dr. McGilligan shared, “Our experience with GenScript’s project management has been excellent from the start. The initial meeting was professional and set a strong foundation for collaboration with their knowledgeable team. Their process is well-organized, with prompt feedback, regular project updates, and great customer service. The technical team’s expertise really stood out, offering valuable insights and guidance throughout. They consistently met deadlines while maintaining clear communication. GenScript is also competitively priced and flexible, offering troubleshooting and adjustments to the work plan when necessary. Overall, the relationship has evolved into a genuine partnership rather than just a transactional service.“
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