Development and evolution are controlled, to a large degree, by regions of genomic DNA called enhancers that encode binding sites for transcription factor proteins. The binding of activators and repressors increases and reduces gene expression levels, respectively, but it is not understood how combinations of activators and repressors generate precise patterns of transcription during development. Towards this aim, we have developed novel methods to dissect transcriptional enhancers to understand their role in determining patterns of gene expression in the fruit fly, a classic model system. Finally, We will discuss our research focused on developmental networks using our high-throughput robotics and multiomics combined with synthetic biology.
Fast, cost-saving, way to get 100% accurate mutant DNA clones to enable studies of gene regulatory elements, DNA-protein interactions, protein structure/function, enzyme active sites, and novel proteins.
Accurate and efficient assembly and cloning of various predefined DNA fragments to generate a library of cloned constructs strategically assembled in a specific arrangement.
Diverse and fully covered mutant library with unbiased distribution to speed up your discovery workflow.
