Peripherin Antibody, mAb, Mouse

Peripherin is a 57,000 Da Class III intermediate filament subunit found initially in sensory neurons of the peripheral nervous system, which gives the protein its name. Certain sensory neurons in the brain stem express peripherin normally, as do a few cortical and hippocampal neurons. Interestingly, peripherin protein is upregulated in the lower motor neurons that degenerate in Amyotrophic Lateral Sclerosis (ALS), focusing attention on peripherin as a potential contributory factor to this serious human neurodegenerative disease. Peripherin is also expressed in certain neuroendocrine tumors and in the insulinproducing cells of the pancreas.