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Company » Company News » Events » GenScript celebrates the 2017 Nobel Prize of Physiology or Medicine
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Congratulations to Jeffrey C. Hall, Michael Rosbash and Michael W. Young, who are rewarded the 2017 Nobel Prize in Physiology or Medicine for their discoveries of molecular mechanisms controlling the circadian rhythm. All the living organisms have a biological clock that helps them adapt to the regular rhythm of the day and further keep the life homeostasis. In summary, they jointly discovered three key clock genes, Period (PER), Timeless (TIM) and Doubletime (DBT), which play vital functions in controlling circadian rhythm.
To celebrate their awards and acknowledge their contributions on human health, GenScript launches a circadian rhythm related gene ORF clones promotion for all scientists. We are aiming to do our best to support scientific endeavors through offering high-quality products and services all the time.

Circadian rhythm gene ORF cDNA clones promotion!

Circadian rhythm gene ORF cDNA clones promotion list

Please send your desired ORF clones ID with related promotion code to our TAM for the discount price.

Species Gene symbol Accession no. Clone ID * Vector ** Turnaround time *** Price(USD) Price after discount Promotion code ****
Homo sapiens PER1 XM_005256689 OHu15849 pcDNA3.1+/C-(K)DYK Next-day $549 Free 2017NPFree
Homo sapiens PER1 NM_002616 OHu15849 pcDNA3.1+/C-(K)DYK Next-day $549 Free 2017NPFree
Homo sapiens PER2 XM_006712824 OHu23793 pcDNA3.1+/C-(K)DYK Next-day $919 Free 2017NPFree
Homo sapiens PER2 XM_005246111 OHu23793 pcDNA3.1+/C-(K)DYK Next-day $919 Free 2017NPFree
Homo sapiens PER2 NM_022817 OHu23793 pcDNA3.1+/C-(K)DYK Next-day $919 Free 2017NPFree
Homo sapiens PER3 NM_016831 OHu23442 pcDNA3.1+/C-(K)DYK Next-day $1209 Free 2017NPFree
Mus musculus Per2 NM_011066 OMu18864 pcDNA3.1+/C-(K)DYK Next-day $919 Free 2017NPFree
Drosophila melanogaster PER NM_080317 OFa00629 pcDNA3.1+/C-(K)DYK 18 $1019 $509.50 2017NP50
Mus musculus Per1 NM_011065 OMu18208 pcDNA3.1+/C-(K)DYK 20 $919 $459.50 2017NP50
Rattus norvegicus Per1 NM_001034125 ORa13057 pcDNA3.1+/C-(K)DYK 18 $919 $459.50 2017NP50
Rattus norvegicus Per2 NM_031678 ORa13571 pcDNA3.1+/C-(K)DYK 20 $919 $459.50 2017NP50
Mus musculus Per3 NM_011067 OMu58483 pcDNA3.1+/C-(K)DYK 20 $939 $469.50 2017NP50
Rattus norvegicus Per3 NM_023978 ORa06701 pcDNA3.1+/C-(K)DYK 20 $799 $399.50 2017NP50
Drosophila melanogaster TIM NM_001201757 OFa16162 pcDNA3.1+/C-(K)DYK 12-14 $729 $364.50 2017NP50
Drosophila melanogaster TIM NM_001144308 OFa13650 pcDNA3.1+/C-(K)DYK 25 $1139 $569.50 2017NP50
Drosophila melanogaster TIM NM_164540 OFa13651 pcDNA3.1+/C-(K)DYK 25 $1139 $569.50 2017NP50
Drosophila melanogaster TIM NM_001038783 OFa13652 pcDNA3.1+/C-(K)DYK 20 $899 $449.50 2017NP50
Drosophila melanogaster TIM NM_001014463 OFa13653 pcDNA3.1+/C-(K)DYK 20 $899 $449.50 2017NP50
Drosophila melanogaster TIM NM_164542 OFa13651 pcDNA3.1+/C-(K)DYK 25 $1139 $569.50 2017NP50
Drosophila melanogaster TIM NM_164541 OFa13654 pcDNA3.1+/C-(K)DYK 25 $1139 $569.50 2017NP50
Drosophila melanogaster TIM NM_001144309 OFa13655 pcDNA3.1+/C-(K)DYK 12-14 $729 $364.50 2017NP50
Mus musculus Timeless XM_006513583 OMu16520 pcDNA3.1+/C-(K)DYK 20 $919 $459.50 2017NP50
Mus musculus Timeless NM_011589 OMu16520 pcDNA3.1+/C-(K)DYK 20 $919 $459.50 2017NP50
Mus musculus Timeless NM_001164081 OMu16520 pcDNA3.1+/C-(K)DYK 20 $919 $459.50 2017NP50
Homo sapiens Timeless XM_011538939 OHu62315 pcDNA3.1+/C-(K)DYK 20 $919 $459.50 2017NP50
Homo sapiens Timeless NM_003920 OHu26255 pcDNA3.1+/C-(K)DYK 20 $549 $274.50 2017NP50
Rattus norvegicus Timeless NM_031340 ORa07866 pcDNA3.1+/C-(K)DYK 20 $919 $459.50 2017NP50
Drosophila melanogaster DBT NM_001276203 OFa06727 pcDNA3.1+/C-(K)DYK 7-9 $369 $184.50 2017NP50
Drosophila melanogaster DBT NM_170535 OFa06727 pcDNA3.1+/C-(K)DYK 7-9 $369 $184.50 2017NP50
Drosophila melanogaster DBT NM_170536 OFa06727 pcDNA3.1+/C-(K)DYK 7-9 $369 $184.50 2017NP50
Drosophila melanogaster DBT NM_079863 OFa06727 pcDNA3.1+/C-(K)DYK 7-9 $369 $184.50 2017NP50

* One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

*** Business Day

**** Please take note that 2017NPFree can be used once for each account number, 50% off for all the other clones.

Illustration: NobelPrize.org

In 1984, Jeffrey Hall and Michael Rosbash at Brandeis University identified and isolated the Period gene that encodes a protein named PER. They showed that protein PER level peaks at night and decline in daytime following 24-hour cycle. Michael Young at Rockefeller University independently discovered another monumental gene Timeless that encodes TIM protein involved in regulating PER’s cyclic production in cells. The TIM binds to PER and shuttle it from cytoplasm into its nucleus, where it can inhibit the expression of the period gene. Further studies revealed the DBT protein, a kinase that could phosphorylates PER to promote its degradation, triggering the transcription of the clock and clock-controlled genes. Consequently, the oscillations of PER and TIM proteins presence causes oscillations in themselves and other clock genes' expression, which is the basis for circadian rhythmicity.

Their work is very meaningful because the internal biological clock is now well recognized as a key feature of eukaryotic organisms from fruit flies to humans. The beauty biological clocks is that it allows organisms to adapt their physiology to the Earth’s associated rotation daily light cycles, including blood pressure, sleep, body temperature, and metabolism. Numerous evidence suggest that disruption of circadian rhythm may cause serious health problems, for instance, increased risk of cancer. Scientists are now looking to improve treatment of cardiovascular and other diseases by coordinating delivery of drugs with a patient’s clock.

References

Terms and conditions:

  1. Only domestic (US) and international customers, excluding Japan and China, are eligible to attend this promotion.
  2. This promotion is valid until Dec 31, 2017, US-EST time zone.
  3. Please take note that 2017NPFree can be used on next-day clones once for each account number, 50% off for all the other clones.
  4. All next-day shipping ORF clones are expression-ready and delivered in the pcDNA3.1+/C-(K)-DYK vector.
  5. Customer is responsible for paying the shipping fee to receive the free next-day shipping and discounted ORF clone.
  6. All the clones can be cloned into any vectors, additional sub-cloning charge will be applied, please contact our TAM for quotation.
  7. Contact us at gene@genscript.com if you have any questions about this promotion.
 
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