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ToxinEraser™ Endotoxin Removal Kit

GenScript ToxinEraser™ is an endototoxin removal resin of high efficiency. It is based on the affinity matrix of modified polymyxin B (PMB), which allows highly efficient endotoxin removal. The final endotoxin level can be decreased to less than 0.1 EU/ml with repeat use of ToxinEraser™ endotoxin removal resin. Final removal efficiency may vary depending on the sample type/source.
L00338
$126.00

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Overview
Product Description Lipopolysaccharide (LPS) is a bacterial endotoxin, and a major constituent of the cell walls of gram- negative bacteria. During gram-negative bacteremia or endotoxemia, LPS is the principal pathophysiological mediator by which bacteria can cause hypotension, organ failure, disseminated intravascular coagulation, and fatal shock in mammalian hosts. Removal of endotoxin from drugs, injectables, and other biological products is necessary but can also be very difficult.
GenScript’s ToxinEraser™ is an endototoxin removal resin of high efficiency. It is based on affinity matrix of modified polymyxin B (PMB), which allows highly efficient endotoxin removal. The final endotoxin level can be decreased to less than 0.1 EU/ml with repeated use of ToxinEraser™ endotoxin removal resin. Final removal efficiency may vary depending on the sample type/source.
Key Features
  • High stability and high removal efficiency
  • High binding capacity: > 2, 000, 000 EU / ml (CV)
  • Fast flow without any constant speed pump
  • Reusable up to five times if properly regenerated
  • Ready-to-use reagents and materials, such as equilibration buffer, collection tubes, etc.

Product Introduction
Kit Contents
Kit Contents （Cat. No.:L00338） PK
ToxinEraser™ Endotoxin Removal Resin 1.5 ml pre-packed column
Regeneration Buffer 125 ml
Equilibration Buffer 125 ml
Flow-Speed Control 1
Collection Tubes 1 bag (3 Tubes)
Tips (1 ml) 2 bags (6 Tips/bag)
Protocol 1
Product Information Characteristics of ToxinEraser™ Endotoxin Removal Resin
Size1.5 ml in pre-packed column
Binding CapacityUp to 2,000,000 EU/ml resin
LigandModified PMB (Polymixin B)
pH StabilitypH 5 -10
Support Matrix4% cross-linked agarose, spherical beads
Mean Particle Size90 μm
Storage2°C to 8°C (Do not freeze.)
Equilibration BufferPhosphate-Buffer, pH 8.0
Regeneration BufferSodium Phosphate-Buffer, pH 8.0; Triton-114
Types of substances that can be applied to the columnPurified recombinant proteins, peptides, antibodies, polysaccharides, etc.
Tolerable Ionic Strength0.1 to 0.5 M NaCl
Tested reagents that do not interfere with performance
20% DMSO, 20% ethanol, 20% glycerol;1 M urea, 300 mM imidazole; 0.05% Tween 20, 10 mM DTT.
Storage Regeneration and storage of the Column.
To regenerate the column, wash the column with 10 ml of equilibration buffer and allow the column to drain completely. Add ethanol to the regeneration buffer to a final concentration of 20%, adding at least 1.5 ml to the column for storage. Store at 2-8°C. Do not freeze.

For research and manufacturing use. Direct human use, including taking orally and injection are forbidden.


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