Catalog Products » Endotoxin Detection and Removal System » Endotoxin Removal » ToxinEraserTM Endotoxin Removal Resin

ToxinEraser™ Endotoxin Removal Resin

The ToxinEraser™ Endotoxin Removal Resin utilizes immobilized polymixin B to bind and remove pyrogens from solution. The polymixins are a family of antibiotics that contain a cationic cyclopeptide with a fatty acid chain. Polymixin B neutralizes the biological activity of endotoxins by binding to the lipid A portion of bacterial lipopolysaccharide.
L00402
$60.00

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Description

Lipopolysaccharide (LPS) is a bacterial endotoxin, and a major constituent of the cell walls of gram-negative bacteria. During gram-negative bacteremia or endotoxemia, LPS is the principal pathophysiological mediator by which bacteria can cause hypotension, organ failure, disseminated intravascular coagulation, and fatal shock in mammalian hosts. The removal of these endotoxins is highly necessary for downstream processes.


The ToxinEraser Endotoxin Removal Resin utilizes immobilized polymixin B to bind and remove pyrogens from solution. The polymixins are a family of antibiotics that contain a cationic cyclopeptide with a fatty acid chain. Polymixin B neutralizes the biological activity of endotoxins by binding to the lipid A portion of bacterial lipopolysaccharide.

Overview
Product Information
Binding CapacityUp to 2,000,000 EU/ml resin.
LigandModified PMB (Polymixin B)
pH StabilitypH 5 -10
Support Matrix4% cross-linked agarose, spherical beads
Mean Particle Size90 μm
Types of substances that can be applied to the columnProtein, including peptides and antibody, polysaccharide, etc.
Applicable Ionic Strength0.1 to 0.5 M NaCl
Substances tested that do not interfere with performance20% DMSO, 20% ethanol, 20% glycerol; 1 M urea, 300 mM imidazole; 0.05% Tween 20, 10 mM DTT, etc.
Key Features
  • High stability and high removal efficiency.
  • High binding capacity: > 2, 000, 000 EU / ml (CV).
  • Reusable up to five times if properly regenerated.

Properties
Storage & Stability 2°C to 8°C (Do not freeze.)

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