Overview

Endotoxin, also known as Lipopolysaccharide (LPS), is a cell membrane component of Gram-negative bacteria. A single E. coli cell contains about 2 million LPS molecules, which are released into the lysate during cell lysis. Endotoxins can initiate a strong immune response in mammalian hosts, resulting in systemic inflammatory response syndrome (SIRS) and/or sepsis. Endotoxins are often difficult to remove from solution due to the high variability of their molecular weights. In addition, endotoxins are relatively stable and insensitive to changes in temperature and pH.

endotoxin removal

Ligands with affinity to endotoxins can be coupled to an anion exchange system to increase the endotoxin binding strength. ToxinEraser Endotoxin Removal System is based on an affinity matrix of modified polymyxin B (PMB), which allows for efficient endotoxin removal from samples such as proteins, peptides, and antibodies. The final endotoxin level can be decreased to as low as 0.1 EU/ml * with repeated use of ToxinEraser Endotoxin Removal Resin.

*Final removal efficiency may vary depending on the sample type/source.

Key Features

High reproducibility

High binding capacity at least 2, 000, 000 EU/ml (CV)

Competitive price

High Recovery Yield: >90% with minimized sample loss

Broad detection range

High stability and high removal efficiency

Ordering Information

Cat. No. Product Name Quantity Price Order
L00338
ToxinEraser™ Endotoxin Removal Kit
$126.00 1 Kit
 

Related Products

Cat. No. Product Name Quantity Price Order
L00350
ToxinSensor™ Chromogenic LAL Endotoxin Assay Kit
$199.00
 
L00351
ToxinSensor™ Gel Clot Endotoxin Assay Kit
$147.00 1 kit
 
L00402
ToxinEraser™ Endotoxin Removal Resin
$60.00 1 ml Resin (Total 2 ml)
 
M01053
ToxinEraser™ Regeneration Buffer
$25.00 125 ml
 
M01054
ToxinEraser™ Equilibration Buffer
$25.00 125 ml
 
M01063
ToxinSensor™ Endotoxin-free Pipette Tips (1 ml, Blue)
$6.00 1 PK of 6 tips
 

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