|Synonyms||PAR4, Thrombin receptor, PAR-4, proteinase-activated receptor-4, coagulation factor II receptor-like 3, protease-activated receptor 4, proteinase-activated receptor 4, thrombin receptor-like 3|
|Description||Protease-activated receptor (PAR)-4 is a member of a unique family of GPCRs. The protease-activated receptors (PARs) that are activated by proteolytic cleavage of the N-terminal domain of the receptor reveal a tethered ligand. The PAR family consists of 4 receptors; PAR1 and PAR3 are activated by thrombin, and PAR2 and PAR4 are activated by several serine proteases (Macfarlane et al., 2001). PAR4 is a recently identified low-affinity thrombin receptor that plays a pathophysiological role in many types of tissues including the lung. Mice lacking PAR4 are protected from mesenteric arteriole thrombosis, indicating that PAR4 is a potential target for treatment of thrombosis in humans.|
|Culture Medium||Ham's F12, 10% FBS, 400 μg/ml G418|
|Freeze Medium||45% Ham's F12, 45% FBS, and 10% DMSO|
|Storage||Liquid nitrogen immediately upon delivery|
|Functional assay for PAR4 receptor
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