|Synonyms||P2Y1 receptor, Purinergic receptor P2Y1, ATP receptor, P2Y purinoceptor 1, platelet ADP receptor, P2 purinoceptor subtype Y1, P2Y, P2Y ATP receptor 1,P2Y purinoceptor 1|
|Description||P2Y receptors are members of a large family of G protein-coupled receptors that is classified into five functionally characterized human gene products (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11). P2RY1 or P2Y1 is a GPCR that binds to ADP and ATP to activate Gq. P2Y1 express on vascular endothelium and smooth muscle, and mediate vascular tone both in the resting state and in thrombosis, when platelet-derived ATP and ADP are present at high concentrations. In addition, activation of P2Y1 expressed on platelets leads to ADP-induced shape changes and aggregation.|
|Culture Medium||DMEM, 10% FBS, 200 μg/ml Zeocin|
|Freeze Medium||45% culture medium, 45% FBS, 10% DMSO|
|Storage||Liquid nitrogen immediately upon delivery|
|Functional assay for P2Y1 receptor
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