Catalog Products » Stable Cell Lines » Human Recombinant Chemokine Receptor-like 1 Stable Cell Line

CHO-K1/CMKLR1/Gα15 Stable Cell Line

The orphan receptor ChemR23 (also referred to as CMKLR1 or DEZ) is a G-protein coupled receptor (GPCR) with homology to neuropeptide and chemoattractant receptors. ChemR23 is also a Gαi-linked receptor expressed primarily by monocytes, MΦs, and plasmacytoid dendritic cells. CMKLR1 has been shown to be expressed by DC generated in vitro from monocytes, to mediate their migration to the proteolytically regulated chemoattractant chemerin, and CMKLR1 may be a key mediator of pDC recruitment from the blood into tissue sites enriched in active chemerin.
M00301
$8,500.00

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Description

The orphan receptor ChemR23 (also referred to as CMKLR1 or DEZ) is a G-protein coupled receptor (GPCR) with homology to neuropeptide and chemoattractant receptors. ChemR23 is also a Gαi-linked receptor expressed primarily by monocytes, MΦs, and plasmacytoid dendritic cells. CMKLR1 has been shown to be expressed by DC generated in vitro from monocytes, to mediate their migration to the proteolytically regulated chemoattractant chemerin, and CMKLR1 may be a key mediator of pDC recruitment from the blood into tissue sites enriched in active chemerin.

Synonyms

chemerin receptor, Gpcr27, chemokine-like receptor 1, ChemR23, DEZ, CMKLR1, cDEZ, G-protein coupled receptor ChemR23, G-protein coupled receptor DEZ, CHEMERINR, orphan G-protein coupled receptor, Dez, CHEMR23, RvE1, RVER1, resolvin E1 receptor, G-protein coupled chemoattractant-like receptor, chemokine receptor-like 1, TIG2 receptor, tazarotene induced gene 2 receptor

Overview
Applications Functional assay for CMKLR1 receptor

Product Introduction
Storage Liquid nitrogen immediately upon delivery
Species Human

Culture Conditions
Freeze Medium 45% culture medium, 45% FBS (Cat. #10099-141, Gibco), 10% DMSO (Cat. #D2650, Sigma)
Culture Medium Ham’s F-12K (Kaighn’s), 10% FBS, 200 μg/ml Zeocin (Cat. #R250-01, Life Technologies), 100 μg/ml Hygromycin B (Cat. #10687010, Invitrogen)


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