|Synonyms||MC2 receptor, MC2R, ACTH-R, ACTH, ACTHR, melanocortin 2 receptor, adrenocorticotropic hormone receptor|
|Description||The melanocortin receptor 2, MC2 receptor, is Gs-coupled GPCRs expressed in zona fasciculata of the adrenal cortex placental and stimulates production of cortisol. MC2 is a member of the rhodopsin family of 7-transmembrane and it's also known as the ACTH receptor or corticotropin receptor because it is specific for ACTH alone. Activation of the MC2 receptor initiates a cascade of events affecting multiple steps in corticoid steroidogenesis. Mutations in MC2 may result in familial glucocorticoid deficiency, a group of autosomal recessive disorders characterized by resistance to ACTH.|
|Culture Medium||Ham's F12, 10% FBS, 200 μg/ml Zeocin, 100 μg/ml Hygromycin B|
|Freeze Medium||45% culture medium, 45% FBS, 10% DMSO|
|Storage||Liquid nitrogen immediately upon delivery|
|Functional assay for MC2 receptor
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