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Catalog Products » Other Products » Stable Cell Lines » Human Recombinant Melatonin MT1 Receptor Stable Cell Line

CHO-K1/MT1/Gα15 Stable Cell Line


Synonyms Human Recombinant Melatonin MT1 Receptor Stable Cell Line
Description Melatonin binds to two specific G-protein coupled receptors (GPCR), MT1 (MTNR1A/MEL1A) and MT2 (MTNR1B/MEL1B). MT1 receptors signal via inhibitory G proteins (Gαi and Gαo) leading to adenylate cyclase inhibition and possibly inositol phosphate stimulation in recombinant systems. In certain native tissues (e.g. sheep pars tuberalis, rat cerebral and caudal arteries) melatonin responses are presumably mediated through activation of MT1 receptors. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin.
Species Human
Culture Medium Ham's F12, 10% FBS, 200 μg/ml Zeocin, 100 μg/ml Hygromycin B
Freeze Medium 45% culture medium, 45% FBS, 10% DMSO

Storage Liquid nitrogen immediately upon delivery

CHO-K1/MT1/Gα15 Stable Cell Line
CHO-K1/MT1/Gα15 Stable Cell Line




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Cat. No. M00424
Size
Price
2 vials $8500.00
24 hour
 
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