|Synonyms||DP1 receptor, prostaglandin D, DP, DP1, PTGDR1, Ptgdr, Ptgdr2, Ptgdrl, PGD receptor-like, PGD2 receptor-like, prostaglandin D receptor, prostaglandin D receptor-like, prostaglandin D2 receptor, prostaglandin D2 receptor-like, prostanoid DP receptor-like|
|Description||DP1 is a Gs-coupled GPCR expressed in the colon, eye, platelets, eosinophils, that bind to PGD2 and PGE2. DP1 can inhibit platelet aggregation, and also inhibit leukotriene B4 and superoxide anion (O2-) release from human neutrophils. It can relax smooth muscle and regulate eosinophil apoptosis. DP receptor knockout OVA-challenged mice exhibit reduced Th2 cytokine levels and lymphocyte accumulation in the lung. In addition, they failed to produce asthmatic responses.|
|Culture Medium||Ham's F12, 10% FBS, 100 μg/ml Hygromycin B, 200 μg/ml Zeocin|
|Freeze Medium||45% culture medium, 45% FBS, 10% DMSO|
|Storage||Liquid nitrogen immediately upon delivery|
|Functional assay for DP1 receptor
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