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Catalog Products » Other Products » Stable Cell Lines » Human Recombinant EDG4 Lysophospholipid Receptor Stable Cell Line

RH7777/EDG4 Stable Cell Line


Synonyms Human Recombinant EDG4 Lysophospholipid Receptor Stable Cell Line
Description Lysophosphatidic acid (LPA), a bioactive lipid produced by several cell types including postmitotic neurons and activated platelets, is thought to be involved in various biological processes, including brain development. Three cognate G-protein coupled receptors encoded by lpa(1)/lp(A1)/Edg-2/Gpcr26, lpa(2)/lp(A2)/Edg-4, and lpa(3)/lp(A3)/Edg-7 mediate the cellular effects of LPA. However, many LPA-induced responses, including phospholipase C activation, Ca2+ mobilization, adenylyl cyclase activation, proliferation, JNK activation, AKT activation, and stress fiber formation, were absent or severely reduced in embryonic fibroblasts derived from lpa(1)(-/-) lpa(2)(-/-) mice. The lysophosphatidic acid receptor LPA2 or endothelial differentiation, G-protein coupled receptor 4(EDG-4) is expressed most abundantly in testes and peripheral blood leukocytes. It is reported to be a distinctive functional marker for ovarian carcinoma.
Species Human
Culture Medium DMEM, 10% FBS, 100 μg/ml G418
Freeze Medium 45% culture medium, 45%FBS, and 10% DMSO

Storage Liquid nitrogen immediately upon delivery

RH7777/EDG4 Stable Cell Line
RH7777/EDG4 Stable Cell Line




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Cat. No. M00463
Size
Price
2 vials $8500.00
24 hour
 
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