Human Recombinant SST1 Somatostatin Receptor Stable Cell Line
Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SST1 receptor is a Gi/Go-coupled GPCR which is expressed in pancreatic islets, pituitary, Cerebellum (Purkinje cells), frontal cortex (pyramidal cells), hippocampus (CA1-4 subfields and some granule cells of the dentate gyrus). It inhibits cAMP accumulation and stimulates tyrosine phosphatase activity, it also can antiproliferation. GenScript's SST1-expressing stable cell line was made in CHO-K1/Gqi5 host cell and optimized for calcium assays.