|Synonyms||PDCD1 ; CD279; PD-1; SLEB2; hPD-1; hPD-l; hSLE1|
|Description||Programmed cell death protein 1, also known as PD-1 and CD279 (cluster of differentiation 279), is a protein that in humans is encoded by the PDCD1 gene. PD-1, functioning as an immune checkpoint, plays an important role in down regulating the immune system by preventing the activation of T-cells, which in turn reduces autoimmunity and promotes self-tolerance. The inhibitory effect of PD-1 is accomplished through a dual mechanism of promoting apoptosis (programmed cell death) in antigen specific T-cells in lymph nodes while simultaneously reducing apoptosis in regulatory T cells (suppressor T cells).|
|Culture Medium||RPMI Medium 1640, 10% FBS, 0.5 μg/ml Puromycin|
|Freeze Medium||95% complete growth medium, 5% DMSO|
|Storage||Liquid nitrogen immediately upon receiving|
|Binding assay or use as immunogen
For more documents, please visit "Technical Support".