Overview

A pathological hallmark of neurodegenerative diseases is the abnormal aggregation of extracellular or intracellular proteins or peptides such as the beta-amyloid peptides and tau proteins of Alzheimer's Disease, prion proteins of prion-related diseases, or huntingtin proteins of Huntington's Disease. These proteins and peptides deposit on or in neurons, impairing neuronal signaling and causing neuronal death. These aggregates arise due to the intrinsic properties of improperly processed or misfolded proteins which cause them to self-assemble into organized plaques or less-ordered neurofibrillary tangles. Peptides are important tools for neurodegenerative disease research studies and can be used to:

  • Study the physiochemical properties of protein or peptide aggregation.
  • Design and test aggregation inhibitor molecules for future drug development.
  • Characterize the distinct roles of non-aggregative proteins involved in aiding aggregative peptide or protein deposition.
  • Develop vaccines capable of immune clearance of amyloid plaques or other protein aggregates.

Challenges in Neurodegenerative Disease Studies

The major challenge of using neurodegenerative disease peptides for in vitro studies is their propensity for aggregation, which stems from their hydrophobic properties. Synthesis and purification of hydrophobic peptides require expertise in difficult peptide synthesis. GenScript has over 9 years of experience in synthesizing hydrophobic peptides and has developed technology capable of synthesizing soluble neurodegenerative disease peptides. Explore the most well-studied neurodegenerative diseases for which peptides serve as key research tools below. Then, view GenScript's technology, services, and citations to see how we can help accelerate your neurodegenerative disease research.

Alzheimer's Disease Alzheimer's Disease Beta-amyloid peptides
and Tau peptides
Alzheimer's Disease Prion-related Diseases Prion peptides
Alzheimer's Disease Huntington's Disease Huntingtin peptides
GenScript's technology

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