Overview

Alzheimer's Disease (AD) affects 36 million people worldwide and is characterized by two types of hallmark aggregates: Extracellular aggregates formed by beta-amyloid peptides and intracellular neurofibrillary tangles (NFTs) consisting of Tau proteins. AD is the leading cause of dementia. Afflicted patients suffer from progressive memory loss, as well as loss of other cognitive functions.

Beta-amyloid Peptide Research Toolbox

Click beta-amyloid peptide synthesis

Specially synthesized soluble beta-amyloid peptide that can be restored to its insoluble, native form simply by a change in pH (See tab below).

Custom beta-amyloid peptide synthesis

GenScript's PepPower™ synthesis platform can synthesize any beta-amyloid peptide sequence or modified sequence you design regardless of hydrophobicity or complexity.

Custom peptide solubility testing

Personalized solubility test and report prepared by our peptide synthesis experts to help you maximize dissolution of your custom peptide order (See tab below).

Beta-amyloid product peptides

Over 50 beta-amyloid peptide fragments ready for delivery.
View peer-reviewed beta-amyloid research publications that cite GenScript Custom Peptide Synthesis Services
  • Click Beta-amyloid Peptide Synthesis

  • Solubility Testing

Click peptide synthesis is a powerful tool for making naturally insoluble beta-amyloid peptides soluble. The soluble beta-amyloid peptide, (called a click beta-amyloid peptide) is synthesized using a special peptide synthesis method called O-acyl synthesis. This method is used to introduce a strategically placed O-acyl bond in place of a native N-acyl bond in the natural beta-amyloid peptide. The introduction of the O-acyl bond in the newly formed click beta-amyloid peptide enhances the peptide's solubility and decreases self-assembly.

click peptide synthesis of beta amyloid

Upon a pH change, the soluble click beta-amyloid peptide returns to its native, insoluble form. The ability to control the solubility of the beta-amyloid peptide allows for the design of assays to study self-assembly mechanics and the identification of beta-amyloid aggregation inhibitors.

The Origins of Tau Proteins

The physiological role of Tau involves assisting the assembly of tubulin into microtubules, which are key to neuronal development and support. Binding of tubulin to Tau is regulated by phosphorylation and dephosphorylation by kinases and phosphatases, respectively. Hyperphosphorylation of Tau results in aberrant tubulin binding and the subsequent unorganized assembly of Tau proteins into the characteristic neurofibrillary tangles (NFTs) of AD.

Peptides in Tau Assembly Research

The mechanism for Tau NFT assembly is not well understood. Tau peptides and phospho-Tau peptides are useful for:

  1. Studying the mechanics of Tau assembly.
  2. Understanding the functions of proteins and peptides that assist NFT assembly and structure.

Tau Peptide Research Toolbox

Custom Tau and phospho-Tau peptide synthesis

GenScript's PepPower™ synthesis platform can synthesize any Tau or phospho-Tau peptide sequences you design.

Custom peptide solubility testing

Personalized solubility test and report prepared by our peptide synthesis experts to help you maximize dissolution of your custom peptide order.
View peer-reviewed Tau research publications that cite GenScript Custom Peptide Synthesis Services

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