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Catalog Products » Recombinant Proteins » Cytokines » Interleukin-1 beta (IL-1β), Rat (HEK 293-expressed)

IL-1β, Rat (HEK 293-expressed)

Synonyms Catabolin, Lymphocyte-activating factor (LAF), Endogenous Pyrogen (EP), Leukocyte Endogenous Mediator (LEM), Mononuclear Cell Factor (MCF)
Description Interleukin-1β is a proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL-1 alpha and IL-1 beta binds to the same receptor and has similar if not identical biological properties. These cytokines have a broad range of activities including, stimulation of thymocyte proliferation, by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1 beta is a secreted cytokine, IL-1 alpha is predominantly a cell-associated cytokine.
Accession No Q63264
Species Rat
Source HEK 293
Biological Activity ED50 < 10 pg/ml, measured in a cell proliferation assay using D10S cells, corresponding to a specific activity of >1 x 108 units/mg
Sequence
VPIRQLHCRL RDEQQKCLVL SDPCELKALH LNGQNISQQV
VFSMSFVQGE TSNDKIPVAL GLKGLNLYLS CVMKDGTPTL
QLESVDPKQY PKKKMEKRFV FNKIEVKTKV EFESAQFPNW
YISTSQAEHR PVFLGNSNGR DIVDFTMEPV SS

Measured Molecular Weight 17~22 kDa, observed by reducing SDS-PAGE.
Purity > 95% as analyzed by SDS-PAGE.
Formulation Lyophilized after extensive dialysis against PBS.
Reconstitution Reconstituted in ddH2O or PBS at 100 μg/ml.
Endotoxin Level < 0.2 EU/μg, determined by LAL method.
Storage Lyophilized recombinant Rat Interleukin 1β(IL-1β) remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, Rat IL-1β should be stable up to 1 week at 4°C or up to 2 months at -20°C.
Note For research use only




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Cat. No. Z03042
Size
Price
5 ug $65.00
25 ug $159.00
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