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Catalog Products » Recombinant Proteins » Cytokines » Interleukin-21 (IL-21), Human

IL-21, Human

Synonyms Za11
Description Interleukin-21 (IL-21) belongs to the Type I four helix bundle cytokines, and shares the common cytokine receptor γ chain with IL-2, IL-4, IL-7, IL-9, and IL-15. IL-21 is expressed by CD4+ T cells, natural killer (NK) T cells, and Th17 cells, and the IL-21 receptor is highly expressed on CD4+ and CD8+ B cells; indeed, IL-21 plays a pivotal role in the survival and proliferation of B cells, and their differentiation to immunoglobulin (Ig) producing cells. IL-21 up-regulates and down-regulates the production of IgG1 and IgE by B cells, respectively, and diminishes the severity of allergy and asthma. In some case, IL-21 also induces the apoptosis of B cells. The other roles of IL-21 include regulation of innate immune systems, implication on autoimmunity, and antitumor actions.
Recombinant human Interleukin-21 (rhIL-21) produced in E. coli is a single non-glycosylated polypeptide chain containing 132 amino acids. A fully biologically active molecule, rhIL-21 has a molecular mass of 15.4 kDa analyzed by reducing SDS-PAGE and is obtained by proprietary chromatographic techniques at GenScript.
Accession No Q9HBE4
Species Human
Source E. coli
Biological Activity ED50 < 0.5 ng/mL, measured by a cell growth inhibition assay using Mino cells, corresponding to a specific activity of > 2.0× 106 units/mg.
Sequence
MQDRHMIRMR QLIDIVDQLK NYVNDLVPEF LPAPEDVETN
CEWSAFSCFQ KAQLKSANTG NNERIINVSI KKLKRKPPST
NAGRRQKHRL TCPSCDSYEK KPPKEFLERF KSLLQKMIHQ
HLSSRTHGSE DS

Measured Molecular Weight 15.4 kDa, observed by reducing SDS-PAGE.
Purity > 95% by SDS-PAGE analysis.
Formulation Lyophilized after extensive dialysis against PBS.
Reconstitution Reconstituted in ddH2O at 100 μg/mL.
Endotoxin Level < 0.2 EU/μg, determined by LAL method.
Storage Lyophilized recombinant human Interleukin-21 (rhIL-21) remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, rhIL-21 should be stable up to 2 weeks at 4°C or up to 3 months at -20°C.
Note For research use only




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Cat. No. Z03076
Size
Price
50 ug $275.00
10 ug $85.00
1 mg $2100.00