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Catalog Products » Recombinant Proteins » Cytokines » Macrophage Migration Inhibitory Factor (MIF), Human

MIF, Human

Synonyms Macrophage Migration, Inhibitory Factor, GLIF, MMIF, GIF, Glycosylation-inhibiting factor
Description Macrophage Migration Inhibitory Factor (MIF) is a pleiotropic cytokine, existing as a homotrimer in vivo. MIF was originally identified as a T cell derived factor responsible for the inhibition of macrophage migration. However, recently MIF has received much more attention because of its possible roles in angiogenesis and cancer development. MIF is over-expressed in various cancers, including pancreatic, breast, colon, brain, prostate, skin, and lung. The intratumoral expression of MIF is strongly correlated with angiogenic growth factor expression, such as the expression of Interleukin 8 (IL-8) and Vascular Endothelial Growth Factor (VEGF), and with risk of recurrence after resection.
Recombinant human Macrophage Migration Inhibitory Factor (rhMIF) produced in E. coli is a single non-glycosylated polypeptide chain containing 115 amino acids. rhMIF has a molecular mass of 12.5 kDa analyzed by reducing SDS-PAGE and is obtained by proprietary chromatographic techniques at GenScript.
Accession No P14174
Species Human
Source E. coli
Sequence
MPMFIVNTNV PRASVPDGFL SELTQQLAQA TGKPPQYIAV
HVVPDQLMAF GGSSEPCALC SLHSIGKIGG AQNRSYSKLL
CGLLAERLRI SPDRVYINYY DMNAANVGWN NSTFA

Measured Molecular Weight 12.5 kDa, observed by reducing SDS-PAGE.
Purity > 95% as analyzed by SDS-PAGE and HPLC.
Formulation Lyophilized after extensive dialysis against PBS.
Reconstitution Reconstituted in ddH2O at 100 μg/mL.
Endotoxin Level < 0.2 EU/μg, determined by LAL method.
Storage Lyophilized recombinant human Macrophage Migration Inhibitory Factor (rhMIF) remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, rhMIF remains stable up to 2 weeks at 4°C or up to 3 months at -20°C.
Note For research use only




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Cat. No. Z03159
Size
Price
50 ug $159.00
10 ug $65.00
1 mg $1200.00
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