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Catalog Products » Recombinant Proteins » Cytokines » Interleukin-1 Receptor Antagonist (IL-1 RA), Human(HEK 293-expressed)

IL-1 RA, Human(HEK 293-expressed)

Synonyms IL-1RA, ICIL-1RA, IRAP, IL-1RN
Description IL-1 Receptor Antagonist, also known as IL-1RA, ICIL-1RA, IRAP and IL-1RN, is a member of the interleukin 1 cytokine family. It is expressed by monocytes, neutrophils, macrophages, epithelial cells and fibroblasts. IL-1RA inhibits the activity of both IL-1alpha and IL-1beta, and modulates a variety of IL-1 related immune and inflammatory responses. It inhibits the activity of IL-1 by binding to the receptor IL-1R1 and preventing its association with the coreceptor IL-1RAP for signaling. Clinical studies are being conducted to investigate the use of IL-1RA in the treatment of sepsis, rheumatoid arthritis and chronic myelogenous leukemia.
Accession No P18510
Species Human
Source HEK 293
Biological Activity ED50 < 0.1 μg /ml, measured in a neutralization assay using D10S cells in the presence of 50pg/ml Human IL-1a.
Sequence
RPSGRKSSKM QAFRIWDVNQ KTFYLRNNQL VAGYLQGPNV
NLEEKIDVVP IEPHALFLGI HGGKMCLSCV KSGDETRLQL
EAVNITDLSE NRKQDKRFAF IRSDSGPTTS FESAACPGWF
LCTAMEADQP VSLTNMPDEG VMVTKFYFQE DE

Measured Molecular Weight 18-23 kDa, observed by reducing SDS-PAGE.
Purity > 95% as analyzed by SDS-PAGE and HPLC.
Formulation Lyophilized after extensive dialysis against PBS.
Reconstitution Reconstituted in ddH2O or PBS at 100 μg/ml.
Endotoxin Level < 0.2 EU/μg, determined by LAL method.
Storage Lyophilized recombinant human IL-1 Receptor Antagonist remains stable up to 6 months at lower than -70°C from date of receipt. Upon reconstitution, Human IL-1 Receptor Antagonist should be stable up to 1 week at 4°C or up to 2 months at -20°C.
Note For research use only




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Cat. No. Z03169
Size
Price
50 ug $75.00
10 ug $39.00
1 mg $750.00