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Catalog Products » Recombinant Proteins » Cytokines » Interleukin-12 (IL-12), His, Rat

IL-12, His, Rat

Synonyms NKSF, TCMF, CLMF, TSF
Description Interleukin-12 (IL-12), also known as NKSF, TCMF, CLMF and TSF, is a heterodimeric cytokine composed of p35 and p40 subunits. It is produced by monocytes, macrophages, B cells and dendritic cells in response to bacterial lipopolysaccharides and intracellular pathogens. IL-12 signals through the IL-12 receptor complex, which is comprised of IL-12 Rβ1 and IL-12 Rβ2. IL-12 induces the proliferation and activation of hematopoietic stem cells, natural killer cells and T- cells. It is indispensible during the development of Th1 cells, leading to the production of IFN-gamma and IL-2.
Species Rat
Source CHO
Specific Activity ED50< 0.1ng/ml, measured in a cell proliferation assay using 2D6 cells.
Sequence
p35:
RVIPVSGPAK CLNQSQNLLK TTDDMVRTAR EKLKHYSCTA GDIDHEDITR DKTSTLEACL PLELHKNESC LATKETSSII RGSCLPPQKT SLMMTLCLGS IYEDLKMYQS EFQAINAALQ SHNHQQITLD RNMLMAIDEL MRSLNHSGET LHQKAPMGEA DPYRVKMKLC ILLHAFSTRV MTINRVMNYL SSSHHHHHH
p40:
MWELEKDVYV VEVDWRPDAP GETVTLTCDS PEEDDITWTS DQRRGVIGSG KTLTITVREF LDAGQYTCHR GGETLSHSHL LLHKKENGIW STEILKNFKN KTFLKCEAPN YSGRFTCSWL VHRNTDLKFN IKSSSSSPES RAVTCGRASL SAEKVTLNQR DYEKYSVACQ EDVTCPTAEE TLPIELVVEA QQQNKYENYS TSFFIRDIIK PDPPKNLQVK PLKNSQVEVS WEYPDSWSTP HSYFSLKFFV RIQRKKEKTK ETEEECNQKG AFLVEKTSAE VQCKGANICV QAQDRYYNSS CSKWTCVPCR GRS

Measured Molecular Weight 26-28kDa (p35) and 42-45 kDa (p40), observed by reducing SDS-PAGE.
Purity > 95% as analyzed by SDS-PAGE.
Formulation Lyophilized after extensive dialysis against PBS.
Reconstitution Reconstituted in ddH2O or PBS at 100 μg/ml.
Endotoxin Level <0.2 EU/μg, determined by LAL method.
Storage Lyophilized recombinant rat Interleukin-12 (IL-12), His remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, rat Interleukin-12 (IL-12), His should be stable up to 1 week at 4°C or up to 2 months at -20°C.
Note For research use only




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Cat. No. Z03210
Size
Price
50 ug $450.00
10 ug $85.00
1 mg $3200.00
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