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Manual
COAs

ACE-2, hFc, Human

*This product has been discontinued!*

This product is going to be discontinued, and an alternative product for purchase is  Z03516.

Angiotensin-Converting Enzyme 2 (ACE-2) is an integral membrane protein and a zinc metalloprotease of the ACE family. The ACE family includes somatic and germinal ACE. ACE-2 cleaves angiotensins I and II as a carboxypeptidase. ACE-2 converts angiotensin I to angiotensin 1-9, and angiotensin II to angiotensin 1-7. ACE-2 is also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency.
Z03484
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Product Introduction
Species Human
Protein Construction
ACE-2 (Gln18-Ser740)
Accession # Q9BYF1		 hFc
N-term C-term
Purity > 95% as analyzed by SDS-PAGE
Endotoxin Level < 1 EU/μg of protein by LAL method
Biological Activity ACE-2, hFc, Human can bind with S-RBD in functional ELISA assay.
Expression System Human Cells
Theoretical Molecular Weight 110.5 kDa
Formulation Supplied as a solution in 20 mM Tris-HCl, 300 mM NaCl, 1 mM ZnCl2, 10% Glycerol, pH 7.4.
Concentration Please refer to the COA for the specific lot.
Storage & Stability Upon receiving, this product remains stable for up to 6 months at -20°C or below. Avoid repeated freeze-thaw cycles.
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Background
Target Background Angiotensin-Converting Enzyme 2 (ACE-2) is an integral membrane protein and a zinc metalloprotease of the ACE family. The ACE family includes somatic and germinal ACE. ACE-2 cleaves angiotensins I and II as a carboxypeptidase. ACE-2 converts angiotensin I to angiotensin 1-9, and angiotensin II to angiotensin 1-7. ACE 2 is also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. It has high binding affinity to S-RBD.
Synonyms Human Angiotensin-Converting Enzyme 2; ACE-2
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For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.


Citations
Felipe Melo-González, et al. Recognition of Variants of Concern by Antibodies and T Cells Induced by a SARS-CoV-2 Inactivated Vaccine. Front Immunol. (2021-11)
Andrew C. Hunt; Bastian V geli; Ahmed O. Hassan; Laura Guerrero; Weston Kightlinger; Danielle J. Yoesep; Antje Kr ger; Madison DeWinter; Michael S. Diamond; Ashty S. Karim; Michael C. Jewett, et al. A rapid cell-free expression and screening platform for antibody discovery. Nature Communications. (2021-06)
Andrew C. Hunt; Bastian V geli; Ahmed O. Hassan; Laura Guerrero; Weston Kightlinger; Danielle J. Yoesep; Antje Kr ger; Madison DeWinter; Michael S. Diamond; Ashty S. Karim; Michael C. Jewett, et al. A rapid cell-free expression and screening platform for antibody discovery. Nature Communications. (2021-06)
Andrew C. Hunt; Bastian V geli; Ahmed O. Hassan; Laura Guerrero; Weston Kightlinger; Danielle J. Yoesep; Antje Kr ger; Madison DeWinter; Michael S. Diamond; Ashty S. Karim; Michael C. Jewett, et al. A rapid cell-free expression and screening platform for antibody discovery. Nature Communications. (2021-06)
Andrew C. Hunt; Bastian V geli; Ahmed O. Hassan; Laura Guerrero; Weston Kightlinger; Danielle J. Yoesep; Antje Kr ger; Madison DeWinter; Michael S. Diamond; Ashty S. Karim; Michael C. Jewett, et al. A rapid cell-free expression and screening platform for antibody discovery. Nature Communications. (2021-06)
Long SW, et al. Molecular Architecture of Early Dissemination and Massive Second Wave of the SARS-CoV-2 Virus in a Major Metropolitan Area. MBio. (2020-10)
Long SW, et al. Molecular Architecture of Early Dissemination and Massive Second Wave of the SARS-CoV-2 Virus in a Major Metropolitan Area. MBio. (2020-10)
Gorshkov K, et al. Quantum Dot-Conjugated SARS-CoV-2 Spike Pseudo-Virions Enable Tracking of Angiotensin Converting Enzyme 2 Binding and Endocytosis. ACS Nano. (2020-09)