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Inhibition of CHI3L1 attenuates excessive autophagy in intestinal epithelial cells to reduce the severity of necrotizing enterocolitis
Authors: Yihui Li, Wenqiang Sun, Xinyun Jin, Huiwen Li, Xue Liu, Jingtao Bian, Xueping Zhu
Journal: Cell Death Discov
PubMed ID: 40188090
Doi: 10.1038/s41420-025-02443-7.
Products & Services: Proteins, Expression, Isolation and Analysis   
Nanosized Shikonin Disrupts Tumor-cell Mismatch Repair and Synergizes with Manganese to Sensitize Squamous Carcinoma to Immunotherapy
Authors: Shan Yu, Jingyuan Li, Jie Zhang, Guozhong Zeng, Bin Zeng, Shuyuan Song, Zhentao Lao, Haolin Chen, Zhenfu Wen, Zeyu Yang, Xiang Li, Kan Li, Le Yang, Hong Liu, Lixin Liu, Guiqing Liao, Yongming Chen, Yujie Liang
Journal: ACS Nano
PubMed ID: 40190094
Doi: 10.1021/acsnano.4c17090.
Products & Services: Proteins, Expression, Isolation and Analysis   
Cryo-EM structures of the small-conductance Ca2+-activated KCa2.2 channel
Authors: Young-Woo Nam, Dohyun Im, Ana Santa Cruz Garcia, Marios L Tringides, Hai Minh Nguyen, Yan Liu, Razan Orfali, Alena Ramanishka, Grigore Pintilie, Chih-Chia Su, Meng Cui, Diomedes E Logothetis, Edward W Yu, Heike Wulff, K George Chandy, Miao Zhang
Journal: Nat Commun
PubMed ID: 40246884
Doi: /10.1038/s41467-025-59061-1
Products & Services: Gene Synthesis   
Astragalus Polysaccharides Ameliorate Diabetic Bladder Dysfunction via Normalization of Neuromuscular Conduction
Authors: Shaochan Liang, Siyuan Xu, Shenglian Ye, Lang Liang, Hongliang Li, Jiaye Liu, Yao Zhang, Feng Zou, Xiaodan Liang, Bo Tan, Hongying Cao
Journal: J Agric Food Chem
PubMed ID: 40032633
Doi: 10.1021/acs.jafc.4c11577
Products & Services: Proteins, Expression, Isolation and Analysis   
The structure and function of the ghrelin receptor coding for drug actions
Authors: Yuki Shiimura, Dohyun Im, Ryosuke Tany, Hidetsugu Asada, Ryoji Kise, Eon Kurumiya, Hideko Wakasugi-Masuho, Satoshi Yasuda, Kazuma Matsui, Jun-Ichi Kishikawa, Takayuki Kato, Takeshi Murata, Masayasu Kojima, So Iwata, Ikuo Masuho
Journal: Nat Struct Mol Biol
PubMed ID: 39833471
Doi: 39833471
Products & Services: Gene Synthesis   
Molecular mechanism of the arrestin-biased agonism of neurotensin receptor 1 by an intracellular allosteric modulator
Authors: Demeng Sun, Xiang Li, Qingning Yuan, Yuanxia Wang, Pan Shi, Huanhuan Zhang, Tao Wang, Wenjing Sun, Shenglong Ling, Yuanchun Liu, Jinglin Lai, Wenqin Xie, Wanchao Yin, Lei Liu, H. Eric Xu, Changlin Tian
Journal: Cell Res
PubMed ID: 40118988
Doi: doi.org/10.1038/s41422-025-01095-7
Products & Services: Antibody Modification and Purification Services   Proteins, Expression, Isolation and Analysis   
A Functional 3D Biomimetic Osteon Accelerates Bone Regeneration
Authors: Chenxu Zhu, Zexi Li, Xubin Qiu, Baizhen Zhao, Huan Wang, Lijie Wang, Ming Zhuang, Jinbo Liu, Fengxuan Han, Bin Li
Journal: ADVANCED FUNCTIONAL MATERIALS
Doi: 10.1002/adfm.202500603
Products & Services: Proteins, Expression, Isolation and Analysis   
Enhancing the Anticancer Activity of a Carcinoma-Directed Peptide–HLA-I Fusion Protein by Armoring with Mutein IFNα
Authors: Douwe Freerk Samplonius , Anne Paulien van Wijngaarden , Lisanne Koll , Xiurong Ke , Wijnand Helfrich
Journal: Int J Mol Sci
PubMed ID: 40243928
Doi: ijms26073178
Products & Services: Gene Synthesis   
Machine Learning-Aided Identification of Fecal Extracellular Vesicle microRNA Signatures for Noninvasive Detection of Colorectal Cancer
Authors: Zhaowei Zhang, Xuyang Liu, Chuanyue Peng, Rui Du, Xiaoqin Hong, Jia Xu, Jiaming Chen, Xiaomin Li, Yujing Tang, Yuwei Li, Yang Liu, Chen Xu, Dingbin Liu
Journal: ACS Nano
PubMed ID: 40033785
Doi: 10.1021/acsnano.4c16698
Products & Services: Synthetic sgRNA and crRNA Service   GenCrispr Cas9 Genome Editing   
GPR132 regulates the function of NK cells through the Gαs/CSK/ZAP70/NF-κB signaling pathway as a potential immune checkpoint
Authors: Xinhui Hui, Min Xue, Yaojun Ren, Yiran Chen, Xuenan Chen, Muhammad Asad Farooq, Yuzhou Ji, Weirong Zhan, Yunhe Huang, Bingtan Du, Jie Yao, Yixin Duan, Wenzheng Jiang
Journal: Sci Adv
PubMed ID: 40043109
Doi: doi/10.1126/sciadv.adr9395
Products & Services: Proteins, Expression, Isolation and Analysis   
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