ToxinSensor™ Chromogenic LAL Endotoxin Assay Kit

GenScript ToxinSensor™ Endotoxin Detection System is an in vitro end-point endotoxin test system for human and animal parenteral drugs, biological products, and medical devices. The system is not intended for detection of endotoxin in a licensed reagent, clinical samples or the diagnosis of human disease. For end-point chromogenic method(Cat. No.: L00350 & L00350C), a measurable endotoxin concentration range from 0.01 to 1 EU/mL can be achieved. For the gel method( Cat. No.: L00351), the sensitivity is 0.25 EU/mL. LAL (Lyophilized Amebocyte Lysate) reagent is made from amebocyte lysate from the horseshoe crab (Limulus polyphemus). These kits can be used according to the bacterial endotoxin test method of the US Pharmacopoeia and the Chinese Pharmacopoeia.

Price	$110.00
Cat. No.	L00350C
Size	1 Kit (16 rxns) 1 Kit (32 rxns) Buy in bulk
Quantity
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Product Introduction Bottom Notes

Note

For specimen preparation, the specimen should be certified free of Beta Glucans contaminant.

Product Introduction

Product Description

Key Features

● Good linearity and good reproducibility
● High sensitivity and board application range
● Ready-to-use reagents and materials

Storage

Please store L00350Y, L00350CY at 2-8°C and store L00350, L00350C at cool and dark place. Do NOT freeze the kit or any of its components.

Kit Contents

Cat. No.	Components	Specific components	Storage
L00350 (32 assays)	L00350	LAL Reagent Water	Store at RT for 24 months
		Color - stabilizer #1
		Color - stabilizer #2
		Color - stabilizer #3
		Endotoxin - free Vials
		Endotoxin - free Tips, 200 μL
		Endotoxin - free Tips, 1 mL
		Incubation Rack
	L00350Y	LAL	Store at RT for 1 month Store at 2 - 8°C for 24 months
		E. coli Endotoxin Standard
		Chromogenic Substrate
L00350C (16 assays)	L00350C	LAL Reagent Water	Store at RT for 24 months
		Color - stabilizer #1
		Color - stabilizer #2
		Color - stabilizer #3
		Endotoxin - free Vials
		Endotoxin - free Tips, 200 μL
		Endotoxin - free Tips, 1 mL
		Incubation Rack
	L00350CY	LAL	Store at RT for 1 month Store at 2 - 8°C for 24 months
		E. coli Endotoxin Standard
		Chromogenic Substrate

*DO NOT FREEZE ANY COMPONENTS!

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ToxinSensor™ Chromogenic LAL Endotoxin Assay Kit

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.

Citations

1. Kaiyuan Yu, et al. A Microbial Lipid-ATP Synthase Axis Fuels NK Cell Antitumor Activity. Advanced Science. (2026-04)
2. Ambroise Wonkam, et al. FLT1 and other candidate fetal haemoglobin modifying loci in sickle cell disease in African ancestries. Nature Communications. (2025-03)
3. Tao Wang, et al. Recombinant Art v401 protein produces immunological tolerance by subcutaneous immunotherapy in a wormwood pollen-driven allergic asthma female mouse model. PLoS ONE. (2024-06)
4. Linfu Chen a, et al. An emerging antibacterial nanovaccine for enhanced chemotherapy by selectively eliminating tumor-colonizing bacteria. Science Bulletin. (2024-06)
5. Kai-Jie He, et al. LRRK2 G2019S promotes astrocytic inflammation induced by oligomeric α-synuclein through NF-κB pathway. iScience. (2023-10)
6. Yin-Feng Kang , et al. Quadrivalent mosaic HexaPro-bearing nanoparticle vaccine protects against infection of SARS-CoV-2 variants. Nat Commun. (2022-05)
7. Yeting Wu, et al. Fish allergens of turbot () parvalbumin triggers food allergy inducing maturation of bone marrow derived dendritic cells and driving Th2 immune response. Food Funct. (2022-04)
8. Mansour Haidar, et al. Targeting lipophagy in macrophages improves repair in multiple sclerosis. Autophagy. (2022-03)
9. Sudeep Ghimire, et al. Dietary Isoflavones Alter Gut Microbiota and Lipopolysaccharide Biosynthesis to Reduce Inflammation. Gut Microbes. (2022-01)
10. Yu-Tang Tung, et al. Djulis Hull Improves Insulin Resistance and Modulates the Gut Microbiota in High-Fat Diet (HFD)-Induced Hyperglycaemia. Antioxidants (Basel). (2021-12)
11. Haoming Wu, et al. Alkaline phosphatase attenuates LPS-induced liver injury by regulating the miR-146a-related inflammatory pathway. Int Immunopharmacol. (2021-10)
12. Brandon Faubert, et al. Stable isotope tracing to assess tumor metabolism in vivo. Nat Protoc. (2021-09)
13. Ting Bei, et al. Antioxidant Fusion Protein SOD1-Tat Increases the Engraftment Efficiency of Total Bone Marrow Cells in Irradiated Mice. Molecules. (2021-06)
14. Julia Koerner, et al. PLGA-particle vaccine carrying TLR3/RIG-I ligand Riboxxim synergizes with immune checkpoint blockade for effective anti-cancer immunotherapy. Nat Commun. (2021-05)
15. Sun Q, et al. Efficient preparation of c-di-AMP at gram-scale using an immobilized Vibrio cholerae dinucleotide cyclase DncV. Enzyme and Microbial Technology. (2021-02)
16. Dina B AbuSamra, et al. Induction of CXCL10-Mediated Cell Migration by Different Types of Galectins. Cells. (2021-01)
17. Wei Shi, et al. Dysregulation of hepatic microRNA expression in C57BL/6 mice affected by excretory-secretory products of Fasciola gigantica. PLoS Negl Trop Dis. (2020-12)
18. Goh JY, et al. Gestational poly(I:C) attenuates, not exacerbates, the behavioral, cytokine and mTOR changes caused by isolation rearing in a rat 'dual-hit' model for neurodevelopmental disorders. Brain, behavior, and immunity. (2020-10)
19. Pittman DW, et al. Behavioral and neurophysiological taste responses to sweet and salt are diminished in a model of subclinical intestinal inflammation. Scientific REPORTS. (2020-10)
20. Wu J, et al. Immunity-and-matrix-regulatory cells derived from human embryonic stem cells safely and effectively treat mouse lung injury and fibrosis. Cell Research . (2020-09)
21. Schneier M, et al. Current technologies to endotoxin detection and removal for biopharmaceutical purification. Biotechnology and bioengineering. (2020-08)
22. Honda Y, et al. Augmentation of Bone Regeneration by Depletion of Stress-Induced Senescent Cells Using Catechin and Senolytics. International Journal of Molecular Sciences. (2020-06)
23. Jun Wu, et al. Immunity-and-Matrix-Regulatory Cells Derived from Human Embryonic Stem Cells Safely and Effectively Treat Mouse Lung Injury and Fibrosis. biorxiv. (2020-04)
24. Honda A, et al. Regulation of bile acid metabolism in mouse models with hydrophobic bile acid composition. J Lipid Res. (2020)
25. S.H.PriyankaA.J.ThusharaArun A.RaufM.Indira, et al. Alcohol induced NLRP3 inflammasome activation in the brain of rats is attenuated by ATRA supplementation. Brain, Behavior, & Immunity - Health. (2020)
26. Zierden HC, et al. Characterization of an Adapted Murine Model of Intrauterine Inflammation-Induced Preterm Birth. Am J Pathol. (2020)
27. Liudmyla Kondratova, et al. Removal Endotoxin From rAAV Samples Using Simple Detergent-based Protocol. Molecular Therapy. (2019-09)
28. KowashH M, et al. Poly(I:C) source， molecular weight and endotoxin contamination affect dam and prenatal outcomes， implications for models of maternal immune activation. Brain Behav Immun. (2019-08)
29. LeeJi Sun, et al. Impact of dynamin 2 on adenovirus nuclear entry. Virology. (2019-03)
30. Dinarvand P, et al. Plasmodium falciparum histidine rich protein HRPII inhibits the anti-inflammatory function of antithrombin. J Thromb Haemost. (2019)
31. Pandya UM, et al. The Biophysical Interaction of the Danger-Associated Molecular Pattern (DAMP) Calreticulin with the Pattern-Associated Molecular Pattern (PAMP) Lipopolysaccharide. Int J Mol Sci. (2019)
32. KeithBrandon A, et al. Von Willebrand Factor Type A domain of hCLCA1 is sufficient for U-937 macrophage activation. Biochem Biophys Rep. (2019)
33. Zhao J, et al. Releasing Behavior of Lipopolysaccharide from Gelatin Modulates Inflammation, Cellular Senescence, and Bone Formation in Critical-Sized Bone Defects in Rat Calvaria. Materials (Basel). (2019)
34. Kondratova L1, et al. Removal of Endotoxin from rAAV Samples Using a Simple Detergent-Based Protocol. Mol Ther Methods Clin Dev. (2019)
35. Adjei-FremahSarah, et al. Cowpea polyphenol extract regulates galectin gene expression in bovine blood. Anim. Biotechnol. (2019)
36. Platnich JM, et al. Shiga Toxin/Lipopolysaccharide Activates Caspase-4 and Gasdermin D to Trigger Mitochondrial Reactive Oxygen Species Upstream of the NLRP3 Inflammasome. Cell Reports. (2018-11)
37. AbouelkhairMohamed A, et al. Characterization of a leukocidin identified in Staphylococcus pseudintermedius. PLoS ONE. (2018-09)
38. Tuuli Ahlstrand, et al. Aggregatibacter actinomycetemcomitans LPS binds human interleukin-8. Journal of Oral Microbiology. (2018)
39. YokoyamaShigetoshi, et al. A novel pathway of LPS uptake through syndecan-1 leading to pyroptotic cell death. Elife. (2018)
40. Lee YT, et al. Intranasal vaccination with M2e5x virus-like particles induces humoral and cellular immune responses conferring cross-protection against heterosubtypic influenza viruses. PLoS ONE. (2018)
41. Drolia Rishi, et al. Listeria Adhesion Protein Induces Intestinal Epithelial Barrier Dysfunction for Bacterial Translocation. Cell Host Microbe. (2018)
42. Murano T, et al. Transcription factor TFEB cell-autonomously modulates susceptibility to intestinal epithelial cell injury in vivo. Scientific REPORTS. (2017-10)
43. PhongsisayVongsavanh, et al. Pertussis toxin targets the innate immunity through DAP12， FcRγ， and MyD88 adaptor proteins. Immunobiology. (2017-04)
44. Xu Z, et al. Innate scavenger receptor-A regulates adaptive T helper cell responses to pathogen infection. Nat Commun. (2017)
45. Toopcham Tidarat, et al. Immunomodulatory activity of protein hydrolysates derived from Virgibacillus halodenitrificans SK1-3-7 proteinase. Food Chem. (2017)
46. Das S, et al. Hyperoxidized albumin modulates neutrophils to induce oxidative stress and inflammation in severe alcoholic hepatitis. Hepatology. (2017)
47. KernPhilip A, et al. Effects of KDT501 on Metabolic Parameters in Insulin-Resistant Prediabetic Humans. J Endocr Soc. (2017)
48. H Tan, et al. Nerve growth factor promotes expression of costimulatory molecules and release of cytokines in dendritic cells involved in Th2 response through LPS-induced p75NTR. J Asthma. (2016-12)
49. Chung PH, et al. Lactobacillus salivarius reverse diabetes-induced intestinal defense impairment in mice through non-defensin protein. J Nutr Biochem. (2016-09)
50. Patel S, et al. Vitamin A or E and a catechin synergize as vaccine adjuvant to enhance immune responses in mice by induction of early interleukin-15 but not interleukin-1β responses. Immunology. (2016-08)
51. MM Sauter, et al. Primate neural retina upregulates IL-6 and IL-10 in response to a herpes simplex vector suggesting the presence of a pro-/anti-inflammatory axis. Exp Eye Res. (2016-07)
52. HwangInjae, et al. Alteration of gut microbiota by vancomycin and bacitracin improves insulin resistance via glucagon-like peptide 1 in diet-induced obesity. FASEB J. (2015-06)
53. Cox-YorkKimberly A, et al. Ovariectomy results in differential shifts in gut microbiota in low versus high aerobic capacity rats. Physiol Rep. (2015)
54. PhongsisayVongsavanh, et al. Evidence for TLR4 and FcRγ-CARD9 activation by cholera toxin B subunit and its direct bindings to TREM2 and LMIR5 receptors. Mol. Immunol. (2015)
55. Phongsisay V, et al. Toll-like receptors recognize distinct proteinase-resistant glycoconjugates in Campylobacter jejuni and Escherichia coli. Mol Immunol. (2014-12)
56. V Phongsisay, et al. LMIR5 extracellular domain activates myeloid cells through Toll-like receptor 4. Mol Immunol. (2014-07)
57. Kampe K, et al. Susceptibility of podocytes to palmitic acid is regulated by fatty acid oxidation and inversely depends on acetyl-CoA carboxylases 1 and 2. Am J Physiol Renal Physiol. (2014-02)
58. Abhilash PA, et al. Ascorbic acid suppresses endotoxemia and NF-κB signalling cascade in alcoholic liver fibrosis in guinea pigs: A mechanistic approach. Toxicol Appl Pharmacol. (2013-11)
59. Bastiaan-Net S, et al. Biochemical And Functional Characterization Of Recombinant Fungal Immunomodulatory Proteins (Rfips). Int Immunopharmacol. (2013-02)
60. Wasaporn Chanput, et al. β-Glucans are involved in immune-modulation of THP-1 macrophages. Mol Nutr Food Res. (2012-05)
61. Yu M, et al. A novel retinoic acid, catechin hydrate and mustard oil-based emulsion for enhanced cytokine and antibody responses against multiple strains of HIV-1 following mucosal and systemic vaccinations. Vaccine. (2011-03)
62. Sharon Altmann, et al. Evaluation of Therapeutic Interventions for Vaccinia Virus Keratitis. J Infect Dis. (2011-03)
63. Tukaj S, et al. Hsp40 proteins modulate humoral and cellular immune response in rheumatoid arthritis patients. Cell Stress Chaperones. (2010-09)
64. Sharon Altmann, et al. Kinetics of Immune Cell Infiltration in Vaccinia Virus Keratitis. Invest Ophthalmol Vis Sci. (2010-09)
65. Sharon Altmann, et al. A Quantitative Rabbit Model of Vaccinia Keratitis. Invest Ophthalmol Vis Sci. (2010-09)

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