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Induction of CXCL10-Mediated Cell Migration by Different Types of Galectins

Cells. 2021-01; 
Dina B AbuSamra, Noorjahan Panjwani, Pablo Argüeso
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Polyclonal Antibody Services … The absence of lipopolysaccharide was confirmed using the ToxinSensor Chromogenic LAL Endotoxin Assay Kit (cat. no. L00350, GenScript, Piscataway, NJ, USA). Protein solutions were concentrated by Amcon ® centrifugal filtration 3K (cat. no … Get A Quote


Chemokines are an extended group of chemoattractant cytokines responsible for the recruitment of leukocytes into tissues. Among them, interferon-γ-inducible protein 10 (CXCL10) is abundantly expressed following inflammatory stimuli and participates in the trafficking of monocytes and activated T cells into sites of injury. Here, we report that different members of the galectin family of carbohydrate-binding proteins promote the expression and synthesis of CXCL10 independently of interferon-γ. Interestingly, CXCL10 induction was observed when galectins came in contact with stromal fibroblasts isolated from human cornea but not other cell types such as epithelial, monocytic or endothelial cells. Induction of CX... More


CXCL10, T cell, chemotaxis, galectins, monocytes