About the Extracellular matrix organization pathway
The extracellular matrix is a component of all mammalian tissues, a network consisting largely of the fibrous proteins collagen, elastin and associated-microfibrils, fibronectin and laminins embedded in a viscoelastic gel of anionic proteoglycan polymers. It performs many functions in addition to its structural role; as a major component of the cellular microenvironment it influences cell behaviours such as proliferation, adhesion and migration, and regulates cell differentiation and death (Hynes 2009).
The longest variant of each gene is displayed. Click the see gene variants link to see all gene variants.
267 gene Click for more »
| Gene Symbol | Full Name |
|---|---|
| A2M | alpha-2-macroglobulin |
| ACTN1 | actinin, alpha 1 |
| ADAM8 | ADAM metallopeptidase domain 8 |
| ADAM10 | ADAM metallopeptidase domain 10 |
| ACAN | aggrecan |
| BGN | biglycan |
| CEACAM1 | carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) |
| BMP1 | bone morphogenetic protein 1 |
| BMP2 | bone morphogenetic protein 2 |
| BMP4 | bone morphogenetic protein 4 |
| BMP7 | bone morphogenetic protein 7 |
| DST | dystonin |
| BSG | basigin (Ok blood group) |
| DDR1 | discoidin domain receptor tyrosine kinase 1 |
| CAPN1 | calpain 1, (mu/I) large subunit |
| CAPNS1 | calpain, small subunit 1 |
| CASP3 | caspase 3, apoptosis-related cysteine peptidase |
| SERPINH1 | serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) |
| CD44 | CD44 molecule (Indian blood group) |
| CD47 | CD47 molecule |
| CD151 | CD151 molecule (Raph blood group) |
| CDH1 | cadherin 1, type 1 |
| CEACAM8 | carcinoembryonic antigen-related cell adhesion molecule 8 |
| CMA1 | chymase 1, mast cell |
| COL1A1 | collagen, type I, alpha 1 |
| COL1A2 | collagen, type I, alpha 2 |
| COL2A1 | collagen, type II, alpha 1 |
| COL3A1 | collagen, type III, alpha 1 |
| COL4A1 | collagen, type IV, alpha 1 |
| COL4A2 | collagen, type IV, alpha 2 |
| COL4A3 | collagen, type IV, alpha 3 (Goodpasture antigen) |
| COL4A4 | collagen, type IV, alpha 4 |
| COL4A5 | collagen, type IV, alpha 5 |
| COL4A6 | collagen, type IV, alpha 6 |
| COL5A1 | collagen, type V, alpha 1 |
| COL5A2 | collagen, type V, alpha 2 |
| COL6A1 | collagen, type VI, alpha 1 |
| COL6A2 | collagen, type VI, alpha 2 |
| COL6A3 | collagen, type VI, alpha 3 |
| COL7A1 | collagen, type VII, alpha 1 |
| COL8A1 | collagen, type VIII, alpha 1 |
| COL8A2 | collagen, type VIII, alpha 2 |
| COL9A1 | collagen, type IX, alpha 1 |
| COL9A2 | collagen, type IX, alpha 2 |
| COL9A3 | collagen, type IX, alpha 3 |
| COL10A1 | collagen, type X, alpha 1 |
| COL11A1 | collagen, type XI, alpha 1 |
| COL11A2 | collagen, type XI, alpha 2 |
| COL12A1 | collagen, type XII, alpha 1 |
| COL13A1 | collagen, type XIII, alpha 1 |
| COL15A1 | collagen, type XV, alpha 1 |
| COL16A1 | collagen, type XVI, alpha 1 |
| COL17A1 | collagen, type XVII, alpha 1 |
| COL19A1 | collagen, type XIX, alpha 1 |
| COMP | cartilage oligomeric matrix protein |
| HAPLN1 | hyaluronan and proteoglycan link protein 1 |
| VCAN | versican |
| NCAN | neurocan |
| CTRB1 | chymotrypsinogen B1 |
| CTSB | cathepsin B |
| CTSD | cathepsin D |
| CTSG | cathepsin G |
| CTSK | cathepsin K |
| CTSL | cathepsin L |
| CTSV | cathepsin V |
| CTSS | cathepsin S |
| DAG1 | dystroglycan 1 (dystrophin-associated glycoprotein 1) |
| DCN | decorin |
| DMD | dystrophin |
| DMP1 | dentin matrix acidic phosphoprotein 1 |
| DSPP | dentin sialophosphoprotein |
| ELANE | elastase, neutrophil expressed |
| ELN | elastin |
| FBLN1 | fibulin 1 |
| FBLN2 | fibulin 2 |
| FBN1 | fibrillin 1 |
| FBN2 | fibrillin 2 |
| EFEMP1 | EGF containing fibulin-like extracellular matrix protein 1 |
| FGA | fibrinogen alpha chain |
| FGB | fibrinogen beta chain |
| FGF2 | fibroblast growth factor 2 (basic) |
| FGG | fibrinogen gamma chain |
| FMOD | fibromodulin |
| FN1 | fibronectin 1 |
| HSPG2 | heparan sulfate proteoglycan 2 |
| TNC | tenascin C |
| IBSP | integrin-binding sialoprotein |
| ICAM1 | intercellular adhesion molecule 1 |
| ICAM2 | intercellular adhesion molecule 2 |
| ICAM3 | intercellular adhesion molecule 3 |
| ICAM4 | intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) |
| ITGA6 | integrin, alpha 6 |
| ITGA1 | integrin, alpha 1 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) |
| ITGA2B | integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) |
| ITGA4 | integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) |
| ITGA7 | integrin, alpha 7 |
| ITGA9 | integrin, alpha 9 |
