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CASP3 cDNA ORF clone, Homo sapiens(human)

Summary

Gene Symbol CASP3
Entrez Gene ID 836
Full Name caspase 3
Synonyms CPP32,CPP32B,SCA-1
General protein information
Preferred Names

caspase 3

Names

caspase-3
CASP-3
CPP-32
PARP cleavage protease
SREBP cleavage activity 1
apopain
caspase 3, apoptosis-related cysteine peptidase
caspase 3, apoptosis-related cysteine protease
cysteine protease CPP32
procaspase3
protein Yama
Gene Type protein-coding
Organism Homo sapiens(human)
Genome

4

4q35.1
Summary The protein encoded by this gene is a cysteine-aspartic acid protease that plays a central role in the execution-phase of cell apoptosis. The encoded protein cleaves and inactivates poly(ADP-ribose) polymerase while it cleaves and activates sterol regulatory element binding proteins as well as caspases 6, 7, and 9. This protein itself is processed by caspases 8, 9, and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. [provided by RefSeq, Aug 2017].
Disorder MIM:

600636


Reference Sequences (RefSeq)

mRNA and Protein(s)

mRNA Protein Name
XM_011532301.1 XP_011530603.1 caspase-3 isoform X1
NM_001354778.1 NP_001341707.1 caspase-3 isoform a preproprotein
NM_001354777.1 NP_001341706.1 caspase-3 isoform a preproprotein
NM_032991.2 NP_116786.1 caspase-3 isoform a preproprotein
NM_004346.4 NP_004337.2 caspase-3 isoform a preproprotein
NM_001354779.1 NP_001341708.1 caspase-3 isoform b
NM_001354782.1 NP_001341711.1 caspase-3 isoform c
NM_004346.3 NP_004337.2 caspase-3 isoform a preproprotein
NM_001354780.1 NP_001341709.1 caspase-3 isoform b
NM_001354783.1 NP_001341712.1 caspase-3 isoform d
NM_001354781.1 NP_001341710.1 caspase-3 isoform c
NM_001354784.1 NP_001341713.1 caspase-3 isoform e

Pathways from BioSystems


Homologies


Homo sapiens (human) CASP3 NP_004337.2
Canis lupus familiaris (dog) CASP3 NP_001003042.1
Rattus norvegicus (Norway rat) Casp3 NP_037054.1
Gallus gallus (chicken) CASP3 NP_990056.1
CASP3 XP_001083044.1
Anopheles gambiae (African malaria mosquito) CASPS8 XP_318945.3
Xenopus tropicalis (tropical clawed frog) casp3 NP_001120900.1
Pan troglodytes (chimpanzee) CASP3 NP_001012435.1
Bos taurus (cattle) CASP3 NP_001071308.1
Mus musculus (house mouse) Casp3 NP_001271338.1

Gene Ontology

The following CASP3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CASP3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID Accession No. Definition **Vector *Turnaround time Price (USD) Select
OHu19919 NM_004346.4
Latest version!		 Homo sapiens caspase 3 (CASP3), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $99.50-$139.30
$199.00
OHu19919 NM_001354778.1
Latest version!		 Homo sapiens caspase 3 (CASP3), transcript variant 4, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $99.50-$139.30
$199.00
OHu19919 NM_001354777.1
Latest version!		 Homo sapiens caspase 3 (CASP3), transcript variant 3, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $99.50-$139.30
$199.00
OHu19919 NM_032991.2
Latest version!		 Homo sapiens caspase 3 (CASP3), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $99.50-$139.30
$199.00
OHu19919 XM_011532301.1
Latest version!		 Homo sapiens caspase 3 (CASP3), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $99.50-$139.30
$199.00
OHu102828 NM_001354779.1
Latest version!		 Homo sapiens caspase 3 (CASP3), transcript variant 5, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $139.30
$199.00
OHu102828 NM_001354780.1
Latest version!		 Homo sapiens caspase 3 (CASP3), transcript variant 6, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $139.30
$199.00
OHu102810 NM_001354781.1
Latest version!		 Homo sapiens caspase 3 (CASP3), transcript variant 7, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 9-11 $69.30
$99.00
OHu102810 NM_001354782.1
Latest version!		 Homo sapiens caspase 3 (CASP3), transcript variant 8, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 9-11 $69.30
$99.00
OHu102834 NM_001354783.1
Latest version!		 Homo sapiens caspase 3 (CASP3), transcript variant 9, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 9-11 $69.30
$99.00
OHu102839 NM_001354784.1
Latest version!		 Homo sapiens caspase 3 (CASP3), transcript variant 10, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 9-11 $69.30
$99.00
View Old Accession Versions >>
OHu19919 NM_004346.3 Homo sapiens caspase 3 (CASP3), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $99.50-$139.30
$199.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)


CloneID OHu19919
Clone ID Related Accession (Same CDS sequence) XM_011532301.1 , NM_001354778.1 , NM_001354777.1 , NM_032991.2 , NM_004346.4 , NM_004346.3
Accession Version NM_001354778.1 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 834bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2017-12-31
Organism Homo sapiens(human)
Product caspase-3 isoform a preproprotein
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC079257.7 and AC073932.4. Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 4 all encode the same isoform (a). Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC016926.2, SRR1803617.172427.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGGAGAACA CTGAAAACTC AGTGGATTCA AAATCCATTA AAAATTTGGA ACCAAAGATC 
ATACATGGAA GCGAATCAAT GGACTCTGGA ATATCCCTGG ACAACAGTTA TAAAATGGAT 
TATCCTGAGA TGGGTTTATG TATAATAATT AATAATAAGA ATTTTCATAA AAGCACTGGA 
ATGACATCTC GGTCTGGTAC AGATGTCGAT GCAGCAAACC TCAGGGAAAC ATTCAGAAAC 
TTGAAATATG AAGTCAGGAA TAAAAATGAT CTTACACGTG AAGAAATTGT GGAATTGATG 
CGTGATGTTT CTAAAGAAGA TCACAGCAAA AGGAGCAGTT TTGTTTGTGT GCTTCTGAGC 
CATGGTGAAG AAGGAATAAT TTTTGGAACA AATGGACCTG TTGACCTGAA AAAAATAACA 
AACTTTTTCA GAGGGGATCG TTGTAGAAGT CTAACTGGAA AACCCAAACT TTTCATTATT 
CAGGCCTGCC GTGGTACAGA ACTGGACTGT GGCATTGAGA CAGACAGTGG TGTTGATGAT 
GACATGGCGT GTCATAAAAT ACCAGTGGAG GCCGACTTCT TGTATGCATA CTCCACAGCA 
CCTGGTTATT ATTCTTGGCG AAATTCAAAG GATGGCTCCT GGTTCATCCA GTCGCTTTGT 
GCCATGCTGA AACAGTATGC CGACAAGCTT GAATTTATGC ACATTCTTAC CCGGGTTAAC 
CGAAAGGTGG CAACAGAATT TGAGTCCTTT TCCTTTGACG CTACTTTTCA TGCAAAGAAA 
CAGATTCCAT GTATTGTTTC CATGCTCACA AAAGAACTCT ATTTTTATCA CTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001341707.1
CDS264..1097
Translation

Target ORF information:

RefSeq Version NM_001354778.1
Organism Homo sapiens(human)
Definition Homo sapiens caspase 3 (CASP3), transcript variant 4, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001354778.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGGAGAACA CTGAAAACTC AGTGGATTCA AAATCCATTA AAAATTTGGA ACCAAAGATC 
ATACATGGAA GCGAATCAAT GGACTCTGGA ATATCCCTGG ACAACAGTTA TAAAATGGAT 
TATCCTGAGA TGGGTTTATG TATAATAATT AATAATAAGA ATTTTCATAA AAGCACTGGA 
ATGACATCTC GGTCTGGTAC AGATGTCGAT GCAGCAAACC TCAGGGAAAC ATTCAGAAAC 
TTGAAATATG AAGTCAGGAA TAAAAATGAT CTTACACGTG AAGAAATTGT GGAATTGATG 
CGTGATGTTT CTAAAGAAGA TCACAGCAAA AGGAGCAGTT TTGTTTGTGT GCTTCTGAGC 
CATGGTGAAG AAGGAATAAT TTTTGGAACA AATGGACCTG TTGACCTGAA AAAAATAACA 
AACTTTTTCA GAGGGGATCG TTGTAGAAGT CTAACTGGAA AACCCAAACT TTTCATTATT 
CAGGCCTGCC GTGGTACAGA ACTGGACTGT GGCATTGAGA CAGACAGTGG TGTTGATGAT 
GACATGGCGT GTCATAAAAT ACCAGTGGAG GCCGACTTCT TGTATGCATA CTCCACAGCA 
CCTGGTTATT ATTCTTGGCG AAATTCAAAG GATGGCTCCT GGTTCATCCA GTCGCTTTGT 
GCCATGCTGA AACAGTATGC CGACAAGCTT GAATTTATGC ACATTCTTAC CCGGGTTAAC 
CGAAAGGTGG CAACAGAATT TGAGTCCTTT TCCTTTGACG CTACTTTTCA TGCAAAGAAA 
CAGATTCCAT GTATTGTTTC CATGCTCACA AAAGAACTCT ATTTTTATCA CTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu19919
Clone ID Related Accession (Same CDS sequence) XM_011532301.1 , NM_001354778.1 , NM_001354777.1 , NM_032991.2 , NM_004346.4 , NM_004346.3
Accession Version NM_001354777.1 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 834bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-11-25
Organism Homo sapiens(human)
Product caspase-3 isoform a preproprotein
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC079257.7 and AC073932.4. On Aug 29, 2017 this sequence version replaced XM_011532301.1. Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same isoform (a). Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.447.1, SRR1803612.52142.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGGAGAACA CTGAAAACTC AGTGGATTCA AAATCCATTA AAAATTTGGA ACCAAAGATC 
ATACATGGAA GCGAATCAAT GGACTCTGGA ATATCCCTGG ACAACAGTTA TAAAATGGAT 
TATCCTGAGA TGGGTTTATG TATAATAATT AATAATAAGA ATTTTCATAA AAGCACTGGA 
ATGACATCTC GGTCTGGTAC AGATGTCGAT GCAGCAAACC TCAGGGAAAC ATTCAGAAAC 
TTGAAATATG AAGTCAGGAA TAAAAATGAT CTTACACGTG AAGAAATTGT GGAATTGATG 
CGTGATGTTT CTAAAGAAGA TCACAGCAAA AGGAGCAGTT TTGTTTGTGT GCTTCTGAGC 
CATGGTGAAG AAGGAATAAT TTTTGGAACA AATGGACCTG TTGACCTGAA AAAAATAACA 
AACTTTTTCA GAGGGGATCG TTGTAGAAGT CTAACTGGAA AACCCAAACT TTTCATTATT 
CAGGCCTGCC GTGGTACAGA ACTGGACTGT GGCATTGAGA CAGACAGTGG TGTTGATGAT 
GACATGGCGT GTCATAAAAT ACCAGTGGAG GCCGACTTCT TGTATGCATA CTCCACAGCA 
CCTGGTTATT ATTCTTGGCG AAATTCAAAG GATGGCTCCT GGTTCATCCA GTCGCTTTGT 
GCCATGCTGA AACAGTATGC CGACAAGCTT GAATTTATGC ACATTCTTAC CCGGGTTAAC 
CGAAAGGTGG CAACAGAATT TGAGTCCTTT TCCTTTGACG CTACTTTTCA TGCAAAGAAA 
CAGATTCCAT GTATTGTTTC CATGCTCACA AAAGAACTCT ATTTTTATCA CTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001341706.1
CDS226..1059
Translation

Target ORF information:

RefSeq Version NM_001354777.1
Organism Homo sapiens(human)
Definition Homo sapiens caspase 3 (CASP3), transcript variant 3, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001354777.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGGAGAACA CTGAAAACTC AGTGGATTCA AAATCCATTA AAAATTTGGA ACCAAAGATC 
ATACATGGAA GCGAATCAAT GGACTCTGGA ATATCCCTGG ACAACAGTTA TAAAATGGAT 
TATCCTGAGA TGGGTTTATG TATAATAATT AATAATAAGA ATTTTCATAA AAGCACTGGA 
ATGACATCTC GGTCTGGTAC AGATGTCGAT GCAGCAAACC TCAGGGAAAC ATTCAGAAAC 
TTGAAATATG AAGTCAGGAA TAAAAATGAT CTTACACGTG AAGAAATTGT GGAATTGATG 
CGTGATGTTT CTAAAGAAGA TCACAGCAAA AGGAGCAGTT TTGTTTGTGT GCTTCTGAGC 
CATGGTGAAG AAGGAATAAT TTTTGGAACA AATGGACCTG TTGACCTGAA AAAAATAACA 
AACTTTTTCA GAGGGGATCG TTGTAGAAGT CTAACTGGAA AACCCAAACT TTTCATTATT 
CAGGCCTGCC GTGGTACAGA ACTGGACTGT GGCATTGAGA CAGACAGTGG TGTTGATGAT 
GACATGGCGT GTCATAAAAT ACCAGTGGAG GCCGACTTCT TGTATGCATA CTCCACAGCA 
CCTGGTTATT ATTCTTGGCG AAATTCAAAG GATGGCTCCT GGTTCATCCA GTCGCTTTGT 
GCCATGCTGA AACAGTATGC CGACAAGCTT GAATTTATGC ACATTCTTAC CCGGGTTAAC 
CGAAAGGTGG CAACAGAATT TGAGTCCTTT TCCTTTGACG CTACTTTTCA TGCAAAGAAA 
CAGATTCCAT GTATTGTTTC CATGCTCACA AAAGAACTCT ATTTTTATCA CTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu19919
Clone ID Related Accession (Same CDS sequence) XM_011532301.1 , NM_001354778.1 , NM_001354777.1 , NM_032991.2 , NM_004346.4 , NM_004346.3
Accession Version NM_032991.2 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 834bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-11-25
Organism Homo sapiens(human)
Product caspase-3 isoform a preproprotein
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AU127028.1, BC016926.2 and BU753483.1. On Aug 19, 2005 this sequence version replaced NM_032991.1. Transcript Variant: This variant (2, also known as beta) differs in the 5' UTR compared to variant 1. Variants 1, 2, and 3 all encode the same isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.90961.1, SRR1803612.267238.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2148093, SAMEA2149004 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGGAGAACA CTGAAAACTC AGTGGATTCA AAATCCATTA AAAATTTGGA ACCAAAGATC 
ATACATGGAA GCGAATCAAT GGACTCTGGA ATATCCCTGG ACAACAGTTA TAAAATGGAT 
TATCCTGAGA TGGGTTTATG TATAATAATT AATAATAAGA ATTTTCATAA AAGCACTGGA 
ATGACATCTC GGTCTGGTAC AGATGTCGAT GCAGCAAACC TCAGGGAAAC ATTCAGAAAC 
TTGAAATATG AAGTCAGGAA TAAAAATGAT CTTACACGTG AAGAAATTGT GGAATTGATG 
CGTGATGTTT CTAAAGAAGA TCACAGCAAA AGGAGCAGTT TTGTTTGTGT GCTTCTGAGC 
CATGGTGAAG AAGGAATAAT TTTTGGAACA AATGGACCTG TTGACCTGAA AAAAATAACA 
AACTTTTTCA GAGGGGATCG TTGTAGAAGT CTAACTGGAA AACCCAAACT TTTCATTATT 
CAGGCCTGCC GTGGTACAGA ACTGGACTGT GGCATTGAGA CAGACAGTGG TGTTGATGAT 
GACATGGCGT GTCATAAAAT ACCAGTGGAG GCCGACTTCT TGTATGCATA CTCCACAGCA 
CCTGGTTATT ATTCTTGGCG AAATTCAAAG GATGGCTCCT GGTTCATCCA GTCGCTTTGT 
GCCATGCTGA AACAGTATGC CGACAAGCTT GAATTTATGC ACATTCTTAC CCGGGTTAAC 
CGAAAGGTGG CAACAGAATT TGAGTCCTTT TCCTTTGACG CTACTTTTCA TGCAAAGAAA 
CAGATTCCAT GTATTGTTTC CATGCTCACA AAAGAACTCT ATTTTTATCA CTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_116786.1
CDS97..930
Translation

Target ORF information:

RefSeq Version NM_032991.2
Organism Homo sapiens(human)
Definition Homo sapiens caspase 3 (CASP3), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_032991.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGGAGAACA CTGAAAACTC AGTGGATTCA AAATCCATTA AAAATTTGGA ACCAAAGATC 
ATACATGGAA GCGAATCAAT GGACTCTGGA ATATCCCTGG ACAACAGTTA TAAAATGGAT 
TATCCTGAGA TGGGTTTATG TATAATAATT AATAATAAGA ATTTTCATAA AAGCACTGGA 
ATGACATCTC GGTCTGGTAC AGATGTCGAT GCAGCAAACC TCAGGGAAAC ATTCAGAAAC 
TTGAAATATG AAGTCAGGAA TAAAAATGAT CTTACACGTG AAGAAATTGT GGAATTGATG 
CGTGATGTTT CTAAAGAAGA TCACAGCAAA AGGAGCAGTT TTGTTTGTGT GCTTCTGAGC 
CATGGTGAAG AAGGAATAAT TTTTGGAACA AATGGACCTG TTGACCTGAA AAAAATAACA 
AACTTTTTCA GAGGGGATCG TTGTAGAAGT CTAACTGGAA AACCCAAACT TTTCATTATT 
CAGGCCTGCC GTGGTACAGA ACTGGACTGT GGCATTGAGA CAGACAGTGG TGTTGATGAT 
GACATGGCGT GTCATAAAAT ACCAGTGGAG GCCGACTTCT TGTATGCATA CTCCACAGCA 
CCTGGTTATT ATTCTTGGCG AAATTCAAAG GATGGCTCCT GGTTCATCCA GTCGCTTTGT 
GCCATGCTGA AACAGTATGC CGACAAGCTT GAATTTATGC ACATTCTTAC CCGGGTTAAC 
CGAAAGGTGG CAACAGAATT TGAGTCCTTT TCCTTTGACG CTACTTTTCA TGCAAAGAAA 
CAGATTCCAT GTATTGTTTC CATGCTCACA AAAGAACTCT ATTTTTATCA CTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu19919
Clone ID Related Accession (Same CDS sequence) XM_011532301.1 , NM_001354778.1 , NM_001354777.1 , NM_032991.2 , NM_004346.4 , NM_004346.3
Accession Version NM_004346.4 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 834bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-11-25
Organism Homo sapiens(human)
Product caspase-3 isoform a preproprotein
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AU127028.1, BC016926.2 and BU753483.1. On Nov 23, 2018 this sequence version replaced NM_004346.3. Transcript Variant: This variant (1, also known as alpha) encodes the longest isoform (a). Variants 1, 2, and 3 all encode the same isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.181796.1, SRR1803617.172427.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000308394.9/ ENSP00000311032.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length. 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGGAGAACA CTGAAAACTC AGTGGATTCA AAATCCATTA AAAATTTGGA ACCAAAGATC 
ATACATGGAA GCGAATCAAT GGACTCTGGA ATATCCCTGG ACAACAGTTA TAAAATGGAT 
TATCCTGAGA TGGGTTTATG TATAATAATT AATAATAAGA ATTTTCATAA AAGCACTGGA 
ATGACATCTC GGTCTGGTAC AGATGTCGAT GCAGCAAACC TCAGGGAAAC ATTCAGAAAC 
TTGAAATATG AAGTCAGGAA TAAAAATGAT CTTACACGTG AAGAAATTGT GGAATTGATG 
CGTGATGTTT CTAAAGAAGA TCACAGCAAA AGGAGCAGTT TTGTTTGTGT GCTTCTGAGC 
CATGGTGAAG AAGGAATAAT TTTTGGAACA AATGGACCTG TTGACCTGAA AAAAATAACA 
AACTTTTTCA GAGGGGATCG TTGTAGAAGT CTAACTGGAA AACCCAAACT TTTCATTATT 
CAGGCCTGCC GTGGTACAGA ACTGGACTGT GGCATTGAGA CAGACAGTGG TGTTGATGAT 
GACATGGCGT GTCATAAAAT ACCAGTGGAG GCCGACTTCT TGTATGCATA CTCCACAGCA 
CCTGGTTATT ATTCTTGGCG AAATTCAAAG GATGGCTCCT GGTTCATCCA GTCGCTTTGT 
GCCATGCTGA AACAGTATGC CGACAAGCTT GAATTTATGC ACATTCTTAC CCGGGTTAAC 
CGAAAGGTGG CAACAGAATT TGAGTCCTTT TCCTTTGACG CTACTTTTCA TGCAAAGAAA 
CAGATTCCAT GTATTGTTTC CATGCTCACA AAAGAACTCT ATTTTTATCA CTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_004337.2
CDS236..1069
Translation

Target ORF information:

RefSeq Version NM_004346.4
Organism Homo sapiens(human)
Definition Homo sapiens caspase 3 (CASP3), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_004346.4

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGGAGAACA CTGAAAACTC AGTGGATTCA AAATCCATTA AAAATTTGGA ACCAAAGATC 
ATACATGGAA GCGAATCAAT GGACTCTGGA ATATCCCTGG ACAACAGTTA TAAAATGGAT 
TATCCTGAGA TGGGTTTATG TATAATAATT AATAATAAGA ATTTTCATAA AAGCACTGGA 
ATGACATCTC GGTCTGGTAC AGATGTCGAT GCAGCAAACC TCAGGGAAAC ATTCAGAAAC 
TTGAAATATG AAGTCAGGAA TAAAAATGAT CTTACACGTG AAGAAATTGT GGAATTGATG 
CGTGATGTTT CTAAAGAAGA TCACAGCAAA AGGAGCAGTT TTGTTTGTGT GCTTCTGAGC 
CATGGTGAAG AAGGAATAAT TTTTGGAACA AATGGACCTG TTGACCTGAA AAAAATAACA 
AACTTTTTCA GAGGGGATCG TTGTAGAAGT CTAACTGGAA AACCCAAACT TTTCATTATT 
CAGGCCTGCC GTGGTACAGA ACTGGACTGT GGCATTGAGA CAGACAGTGG TGTTGATGAT 
GACATGGCGT GTCATAAAAT ACCAGTGGAG GCCGACTTCT TGTATGCATA CTCCACAGCA 
CCTGGTTATT ATTCTTGGCG AAATTCAAAG GATGGCTCCT GGTTCATCCA GTCGCTTTGT 
GCCATGCTGA AACAGTATGC CGACAAGCTT GAATTTATGC ACATTCTTAC CCGGGTTAAC 
CGAAAGGTGG CAACAGAATT TGAGTCCTTT TCCTTTGACG CTACTTTTCA TGCAAAGAAA 
CAGATTCCAT GTATTGTTTC CATGCTCACA AAAGAACTCT ATTTTTATCA CTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu19919
Clone ID Related Accession (Same CDS sequence) XM_011532301.1 , NM_001354778.1 , NM_001354777.1 , NM_032991.2 , NM_004346.4 , NM_004346.3
Accession Version NM_004346.3 Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 834bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2017-12-31
Organism Homo sapiens(human)
Product caspase-3 isoform a preproprotein
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AU127028.1, BC016926.2 and BU753483.1. On Aug 19, 2005 this sequence version replaced NM_004346.2. Transcript Variant: This variant (1, also known as alpha) encodes the longest isoform (a). Variants 1, 2, 3, and 4 all encode the same isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC016926.2, SRR1803617.172427.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGGAGAACA CTGAAAACTC AGTGGATTCA AAATCCATTA AAAATTTGGA ACCAAAGATC 
ATACATGGAA GCGAATCAAT GGACTCTGGA ATATCCCTGG ACAACAGTTA TAAAATGGAT 
TATCCTGAGA TGGGTTTATG TATAATAATT AATAATAAGA ATTTTCATAA AAGCACTGGA 
ATGACATCTC GGTCTGGTAC AGATGTCGAT GCAGCAAACC TCAGGGAAAC ATTCAGAAAC 
TTGAAATATG AAGTCAGGAA TAAAAATGAT CTTACACGTG AAGAAATTGT GGAATTGATG 
CGTGATGTTT CTAAAGAAGA TCACAGCAAA AGGAGCAGTT TTGTTTGTGT GCTTCTGAGC 
CATGGTGAAG AAGGAATAAT TTTTGGAACA AATGGACCTG TTGACCTGAA AAAAATAACA 
AACTTTTTCA GAGGGGATCG TTGTAGAAGT CTAACTGGAA AACCCAAACT TTTCATTATT 
CAGGCCTGCC GTGGTACAGA ACTGGACTGT GGCATTGAGA CAGACAGTGG TGTTGATGAT 
GACATGGCGT GTCATAAAAT ACCAGTGGAG GCCGACTTCT TGTATGCATA CTCCACAGCA 
CCTGGTTATT ATTCTTGGCG AAATTCAAAG GATGGCTCCT GGTTCATCCA GTCGCTTTGT 
GCCATGCTGA AACAGTATGC CGACAAGCTT GAATTTATGC ACATTCTTAC CCGGGTTAAC 
CGAAAGGTGG CAACAGAATT TGAGTCCTTT TCCTTTGACG CTACTTTTCA TGCAAAGAAA 
CAGATTCCAT GTATTGTTTC CATGCTCACA AAAGAACTCT ATTTTTATCA CTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_004337.2
CDS264..1097
Translation

Target ORF information:

RefSeq Version NM_004346.3
Organism Homo sapiens(human)
Definition Homo sapiens caspase 3 (CASP3), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_004346.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGGAGAACA CTGAAAACTC AGTGGATTCA AAATCCATTA AAAATTTGGA ACCAAAGATC 
ATACATGGAA GCGAATCAAT GGACTCTGGA ATATCCCTGG ACAACAGTTA TAAAATGGAT 
TATCCTGAGA TGGGTTTATG TATAATAATT AATAATAAGA ATTTTCATAA AAGCACTGGA 
ATGACATCTC GGTCTGGTAC AGATGTCGAT GCAGCAAACC TCAGGGAAAC ATTCAGAAAC 
TTGAAATATG AAGTCAGGAA TAAAAATGAT CTTACACGTG AAGAAATTGT GGAATTGATG 
CGTGATGTTT CTAAAGAAGA TCACAGCAAA AGGAGCAGTT TTGTTTGTGT GCTTCTGAGC 
CATGGTGAAG AAGGAATAAT TTTTGGAACA AATGGACCTG TTGACCTGAA AAAAATAACA 
AACTTTTTCA GAGGGGATCG TTGTAGAAGT CTAACTGGAA AACCCAAACT TTTCATTATT 
CAGGCCTGCC GTGGTACAGA ACTGGACTGT GGCATTGAGA CAGACAGTGG TGTTGATGAT 
GACATGGCGT GTCATAAAAT ACCAGTGGAG GCCGACTTCT TGTATGCATA CTCCACAGCA 
CCTGGTTATT ATTCTTGGCG AAATTCAAAG GATGGCTCCT GGTTCATCCA GTCGCTTTGT 
GCCATGCTGA AACAGTATGC CGACAAGCTT GAATTTATGC ACATTCTTAC CCGGGTTAAC 
CGAAAGGTGG CAACAGAATT TGAGTCCTTT TCCTTTGACG CTACTTTTCA TGCAAAGAAA 
CAGATTCCAT GTATTGTTTC CATGCTCACA AAAGAACTCT ATTTTTATCA CTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu19919
Clone ID Related Accession (Same CDS sequence) XM_011532301.1 , NM_001354778.1 , NM_001354777.1 , NM_032991.2 , NM_004346.4 , NM_004346.3
Accession Version XM_011532301.1 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 834bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2016-06-05
Organism Homo sapiens(Human)
Product caspase-3 isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000004.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGGAGAACA CTGAAAACTC AGTGGATTCA AAATCCATTA AAAATTTGGA ACCAAAGATC 
ATACATGGAA GCGAATCAAT GGACTCTGGA ATATCCCTGG ACAACAGTTA TAAAATGGAT 
TATCCTGAGA TGGGTTTATG TATAATAATT AATAATAAGA ATTTTCATAA AAGCACTGGA 
ATGACATCTC GGTCTGGTAC AGATGTCGAT GCAGCAAACC TCAGGGAAAC ATTCAGAAAC 
TTGAAATATG AAGTCAGGAA TAAAAATGAT CTTACACGTG AAGAAATTGT GGAATTGATG 
CGTGATGTTT CTAAAGAAGA TCACAGCAAA AGGAGCAGTT TTGTTTGTGT GCTTCTGAGC 
CATGGTGAAG AAGGAATAAT TTTTGGAACA AATGGACCTG TTGACCTGAA AAAAATAACA 
AACTTTTTCA GAGGGGATCG TTGTAGAAGT CTAACTGGAA AACCCAAACT TTTCATTATT 
CAGGCCTGCC GTGGTACAGA ACTGGACTGT GGCATTGAGA CAGACAGTGG TGTTGATGAT 
GACATGGCGT GTCATAAAAT ACCAGTGGAG GCCGACTTCT TGTATGCATA CTCCACAGCA 
CCTGGTTATT ATTCTTGGCG AAATTCAAAG GATGGCTCCT GGTTCATCCA GTCGCTTTGT 
GCCATGCTGA AACAGTATGC CGACAAGCTT GAATTTATGC ACATTCTTAC CCGGGTTAAC 
CGAAAGGTGG CAACAGAATT TGAGTCCTTT TCCTTTGACG CTACTTTTCA TGCAAAGAAA 
CAGATTCCAT GTATTGTTTC CATGCTCACA AAAGAACTCT ATTTTTATCA CTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_011530603.1
CDS198..1031
Translation

Target ORF information:

RefSeq Version XM_011532301.1
Organism Homo sapiens(Human)
Definition Homo sapiens caspase 3 (CASP3), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_011532301.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
ATGGAGAACA CTGAAAACTC AGTGGATTCA AAATCCATTA AAAATTTGGA ACCAAAGATC 
ATACATGGAA GCGAATCAAT GGACTCTGGA ATATCCCTGG ACAACAGTTA TAAAATGGAT 
TATCCTGAGA TGGGTTTATG TATAATAATT AATAATAAGA ATTTTCATAA AAGCACTGGA 
ATGACATCTC GGTCTGGTAC AGATGTCGAT GCAGCAAACC TCAGGGAAAC ATTCAGAAAC 
TTGAAATATG AAGTCAGGAA TAAAAATGAT CTTACACGTG AAGAAATTGT GGAATTGATG 
CGTGATGTTT CTAAAGAAGA TCACAGCAAA AGGAGCAGTT TTGTTTGTGT GCTTCTGAGC 
CATGGTGAAG AAGGAATAAT TTTTGGAACA AATGGACCTG TTGACCTGAA AAAAATAACA 
AACTTTTTCA GAGGGGATCG TTGTAGAAGT CTAACTGGAA AACCCAAACT TTTCATTATT 
CAGGCCTGCC GTGGTACAGA ACTGGACTGT GGCATTGAGA CAGACAGTGG TGTTGATGAT 
GACATGGCGT GTCATAAAAT ACCAGTGGAG GCCGACTTCT TGTATGCATA CTCCACAGCA 
CCTGGTTATT ATTCTTGGCG AAATTCAAAG GATGGCTCCT GGTTCATCCA GTCGCTTTGT 
GCCATGCTGA AACAGTATGC CGACAAGCTT GAATTTATGC ACATTCTTAC CCGGGTTAAC 
CGAAAGGTGG CAACAGAATT TGAGTCCTTT TCCTTTGACG CTACTTTTCA TGCAAAGAAA 
CAGATTCCAT GTATTGTTTC CATGCTCACA AAAGAACTCT ATTTTTATCA CTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu102828
Clone ID Related Accession (Same CDS sequence) NM_001354779.1 , NM_001354780.1
Accession Version NM_001354779.1 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 756bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-11-25
Organism Homo sapiens(human)
Product caspase-3 isoform b
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC079257.7 and AC073932.4. Transcript Variant: This variant (5), as well as variant 6, encodes isoform b. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.196776.1, SRR1660809.231088.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03267764 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
301
361
421
481
541
601
661
721
ATGGACTCTG GAATATCCCT GGACAACAGT TATAAAATGG ATTATCCTGA GATGGGTTTA 
TGTATAATAA TTAATAATAA GAATTTTCAT AAAAGCACTG GAATGACATC TCGGTCTGGT 
ACAGATGTCG ATGCAGCAAA CCTCAGGGAA ACATTCAGAA ACTTGAAATA TGAAGTCAGG 
AATAAAAATG ATCTTACACG TGAAGAAATT GTGGAATTGA TGCGTGATGT TTCTAAAGAA 
GATCACAGCA AAAGGAGCAG TTTTGTTTGT GTGCTTCTGA GCCATGGTGA AGAAGGAATA 
ATTTTTGGAA CAAATGGACC TGTTGACCTG AAAAAAATAA CAAACTTTTT CAGAGGGGAT 
CGTTGTAGAA GTCTAACTGG AAAACCCAAA CTTTTCATTA TTCAGGCCTG CCGTGGTACA 
GAACTGGACT GTGGCATTGA GACAGACAGT GGTGTTGATG ATGACATGGC GTGTCATAAA 
ATACCAGTGG AGGCCGACTT CTTGTATGCA TACTCCACAG CACCTGGTTA TTATTCTTGG 
CGAAATTCAA AGGATGGCTC CTGGTTCATC CAGTCGCTTT GTGCCATGCT GAAACAGTAT 
GCCGACAAGC TTGAATTTAT GCACATTCTT ACCCGGGTTA ACCGAAAGGT GGCAACAGAA 
TTTGAGTCCT TTTCCTTTGA CGCTACTTTT CATGCAAAGA AACAGATTCC ATGTATTGTT 
TCCATGCTCA CAAAAGAACT CTATTTTTAT CACTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001341708.1
CDS171..926
Translation

Target ORF information:

RefSeq Version NM_001354779.1
Organism Homo sapiens(human)
Definition Homo sapiens caspase 3 (CASP3), transcript variant 5, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001354779.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
ATGGACTCTG GAATATCCCT GGACAACAGT TATAAAATGG ATTATCCTGA GATGGGTTTA 
TGTATAATAA TTAATAATAA GAATTTTCAT AAAAGCACTG GAATGACATC TCGGTCTGGT 
ACAGATGTCG ATGCAGCAAA CCTCAGGGAA ACATTCAGAA ACTTGAAATA TGAAGTCAGG 
AATAAAAATG ATCTTACACG TGAAGAAATT GTGGAATTGA TGCGTGATGT TTCTAAAGAA 
GATCACAGCA AAAGGAGCAG TTTTGTTTGT GTGCTTCTGA GCCATGGTGA AGAAGGAATA 
ATTTTTGGAA CAAATGGACC TGTTGACCTG AAAAAAATAA CAAACTTTTT CAGAGGGGAT 
CGTTGTAGAA GTCTAACTGG AAAACCCAAA CTTTTCATTA TTCAGGCCTG CCGTGGTACA 
GAACTGGACT GTGGCATTGA GACAGACAGT GGTGTTGATG ATGACATGGC GTGTCATAAA 
ATACCAGTGG AGGCCGACTT CTTGTATGCA TACTCCACAG CACCTGGTTA TTATTCTTGG 
CGAAATTCAA AGGATGGCTC CTGGTTCATC CAGTCGCTTT GTGCCATGCT GAAACAGTAT 
GCCGACAAGC TTGAATTTAT GCACATTCTT ACCCGGGTTA ACCGAAAGGT GGCAACAGAA 
TTTGAGTCCT TTTCCTTTGA CGCTACTTTT CATGCAAAGA AACAGATTCC ATGTATTGTT 
TCCATGCTCA CAAAAGAACT CTATTTTTAT CACTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu102828
Clone ID Related Accession (Same CDS sequence) NM_001354779.1 , NM_001354780.1
Accession Version NM_001354780.1 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 756bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-11-25
Organism Homo sapiens(human)
Product caspase-3 isoform b
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC079257.7 and AC073932.4. Transcript Variant: This variant (6), as well as variant 5, encodes isoform b. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660803.229530.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
301
361
421
481
541
601
661
721
ATGGACTCTG GAATATCCCT GGACAACAGT TATAAAATGG ATTATCCTGA GATGGGTTTA 
TGTATAATAA TTAATAATAA GAATTTTCAT AAAAGCACTG GAATGACATC TCGGTCTGGT 
ACAGATGTCG ATGCAGCAAA CCTCAGGGAA ACATTCAGAA ACTTGAAATA TGAAGTCAGG 
AATAAAAATG ATCTTACACG TGAAGAAATT GTGGAATTGA TGCGTGATGT TTCTAAAGAA 
GATCACAGCA AAAGGAGCAG TTTTGTTTGT GTGCTTCTGA GCCATGGTGA AGAAGGAATA 
ATTTTTGGAA CAAATGGACC TGTTGACCTG AAAAAAATAA CAAACTTTTT CAGAGGGGAT 
CGTTGTAGAA GTCTAACTGG AAAACCCAAA CTTTTCATTA TTCAGGCCTG CCGTGGTACA 
GAACTGGACT GTGGCATTGA GACAGACAGT GGTGTTGATG ATGACATGGC GTGTCATAAA 
ATACCAGTGG AGGCCGACTT CTTGTATGCA TACTCCACAG CACCTGGTTA TTATTCTTGG 
CGAAATTCAA AGGATGGCTC CTGGTTCATC CAGTCGCTTT GTGCCATGCT GAAACAGTAT 
GCCGACAAGC TTGAATTTAT GCACATTCTT ACCCGGGTTA ACCGAAAGGT GGCAACAGAA 
TTTGAGTCCT TTTCCTTTGA CGCTACTTTT CATGCAAAGA AACAGATTCC ATGTATTGTT 
TCCATGCTCA CAAAAGAACT CTATTTTTAT CACTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001341709.1
CDS338..1093
Translation

Target ORF information:

RefSeq Version NM_001354780.1
Organism Homo sapiens(human)
Definition Homo sapiens caspase 3 (CASP3), transcript variant 6, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001354780.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
ATGGACTCTG GAATATCCCT GGACAACAGT TATAAAATGG ATTATCCTGA GATGGGTTTA 
TGTATAATAA TTAATAATAA GAATTTTCAT AAAAGCACTG GAATGACATC TCGGTCTGGT 
ACAGATGTCG ATGCAGCAAA CCTCAGGGAA ACATTCAGAA ACTTGAAATA TGAAGTCAGG 
AATAAAAATG ATCTTACACG TGAAGAAATT GTGGAATTGA TGCGTGATGT TTCTAAAGAA 
GATCACAGCA AAAGGAGCAG TTTTGTTTGT GTGCTTCTGA GCCATGGTGA AGAAGGAATA 
ATTTTTGGAA CAAATGGACC TGTTGACCTG AAAAAAATAA CAAACTTTTT CAGAGGGGAT 
CGTTGTAGAA GTCTAACTGG AAAACCCAAA CTTTTCATTA TTCAGGCCTG CCGTGGTACA 
GAACTGGACT GTGGCATTGA GACAGACAGT GGTGTTGATG ATGACATGGC GTGTCATAAA 
ATACCAGTGG AGGCCGACTT CTTGTATGCA TACTCCACAG CACCTGGTTA TTATTCTTGG 
CGAAATTCAA AGGATGGCTC CTGGTTCATC CAGTCGCTTT GTGCCATGCT GAAACAGTAT 
GCCGACAAGC TTGAATTTAT GCACATTCTT ACCCGGGTTA ACCGAAAGGT GGCAACAGAA 
TTTGAGTCCT TTTCCTTTGA CGCTACTTTT CATGCAAAGA AACAGATTCC ATGTATTGTT 
TCCATGCTCA CAAAAGAACT CTATTTTTAT CACTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu102810
Clone ID Related Accession (Same CDS sequence) NM_001354782.1 , NM_001354781.1
Accession Version NM_001354782.1 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 549bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-12-01
Organism Homo sapiens(human)
Product caspase-3 isoform c
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC079257.7 and AC073932.4. Transcript Variant: This variant (8), as well as variant 7, encodes isoform c. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803613.87675.1, SRR1803612.139766.1 [ECO:0000332] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
301
361
421
481
541
ATGGAGAACA CTGAAAACTC AGTGGATTCA AAATCCATTA AAAATTTGGA ACCAAAGATC 
ATACATGGAA GCGAATCAAT GGACTCTGGA ATATCCCTGG ACAACAGTTA TAAAATGGAT 
TATCCTGAGA TGGGTTTATG TATAATAATT AATAATAAGA ATTTTCATAA AAGCACTGGA 
ATGACATCTC GGTCTGGTAC AGATGTCGAT GCAGCAAACC TCAGGGAAAC ATTCAGAAAC 
TTGAAATATG AAGTCAGGAA TAAAAATGAT CTTACACGTG AAGAAATTGT GGAATTGATG 
CGTGATGTTT CTAAAGAAGA TCACAGCAAA AGGAGCAGTT TTGTTTGTGT GCTTCTGAGC 
CATGGTGAAG AAGGAATAAT TTTTGGAACA AATGGACCTG TTGACCTGAA AAAAATAACA 
AACTTTTTCA GAGGGGATCG TTGTAGAAGT CTAACTGGAA AACCCAAACT TTTCATTATT 
CAGGTTATTA TTCTTGGCGA AATTCAAAGG ATGGCTCCTG GTTCATCCAG TCGCTTTGTG 
CCATGCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001341711.1
CDS264..812
Translation

Target ORF information:

RefSeq Version NM_001354782.1
Organism Homo sapiens(human)
Definition Homo sapiens caspase 3 (CASP3), transcript variant 8, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001354782.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
ATGGAGAACA CTGAAAACTC AGTGGATTCA AAATCCATTA AAAATTTGGA ACCAAAGATC 
ATACATGGAA GCGAATCAAT GGACTCTGGA ATATCCCTGG ACAACAGTTA TAAAATGGAT 
TATCCTGAGA TGGGTTTATG TATAATAATT AATAATAAGA ATTTTCATAA AAGCACTGGA 
ATGACATCTC GGTCTGGTAC AGATGTCGAT GCAGCAAACC TCAGGGAAAC ATTCAGAAAC 
TTGAAATATG AAGTCAGGAA TAAAAATGAT CTTACACGTG AAGAAATTGT GGAATTGATG 
CGTGATGTTT CTAAAGAAGA TCACAGCAAA AGGAGCAGTT TTGTTTGTGT GCTTCTGAGC 
CATGGTGAAG AAGGAATAAT TTTTGGAACA AATGGACCTG TTGACCTGAA AAAAATAACA 
AACTTTTTCA GAGGGGATCG TTGTAGAAGT CTAACTGGAA AACCCAAACT TTTCATTATT 
CAGGTTATTA TTCTTGGCGA AATTCAAAGG ATGGCTCCTG GTTCATCCAG TCGCTTTGTG 
CCATGCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu102810
Clone ID Related Accession (Same CDS sequence) NM_001354782.1 , NM_001354781.1
Accession Version NM_001354781.1 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 549bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-11-25
Organism Homo sapiens(human)
Product caspase-3 isoform c
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC079257.7 and AC073932.4. Transcript Variant: This variant (7), as well as variant 8, encodes isoform c. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.176829.1, SRR1803617.97469.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2148093, SAMEA2149004 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
301
361
421
481
541
ATGGAGAACA CTGAAAACTC AGTGGATTCA AAATCCATTA AAAATTTGGA ACCAAAGATC 
ATACATGGAA GCGAATCAAT GGACTCTGGA ATATCCCTGG ACAACAGTTA TAAAATGGAT 
TATCCTGAGA TGGGTTTATG TATAATAATT AATAATAAGA ATTTTCATAA AAGCACTGGA 
ATGACATCTC GGTCTGGTAC AGATGTCGAT GCAGCAAACC TCAGGGAAAC ATTCAGAAAC 
TTGAAATATG AAGTCAGGAA TAAAAATGAT CTTACACGTG AAGAAATTGT GGAATTGATG 
CGTGATGTTT CTAAAGAAGA TCACAGCAAA AGGAGCAGTT TTGTTTGTGT GCTTCTGAGC 
CATGGTGAAG AAGGAATAAT TTTTGGAACA AATGGACCTG TTGACCTGAA AAAAATAACA 
AACTTTTTCA GAGGGGATCG TTGTAGAAGT CTAACTGGAA AACCCAAACT TTTCATTATT 
CAGGTTATTA TTCTTGGCGA AATTCAAAGG ATGGCTCCTG GTTCATCCAG TCGCTTTGTG 
CCATGCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001341710.1
CDS97..645
Translation

Target ORF information:

RefSeq Version NM_001354781.1
Organism Homo sapiens(human)
Definition Homo sapiens caspase 3 (CASP3), transcript variant 7, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001354781.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
ATGGAGAACA CTGAAAACTC AGTGGATTCA AAATCCATTA AAAATTTGGA ACCAAAGATC 
ATACATGGAA GCGAATCAAT GGACTCTGGA ATATCCCTGG ACAACAGTTA TAAAATGGAT 
TATCCTGAGA TGGGTTTATG TATAATAATT AATAATAAGA ATTTTCATAA AAGCACTGGA 
ATGACATCTC GGTCTGGTAC AGATGTCGAT GCAGCAAACC TCAGGGAAAC ATTCAGAAAC 
TTGAAATATG AAGTCAGGAA TAAAAATGAT CTTACACGTG AAGAAATTGT GGAATTGATG 
CGTGATGTTT CTAAAGAAGA TCACAGCAAA AGGAGCAGTT TTGTTTGTGT GCTTCTGAGC 
CATGGTGAAG AAGGAATAAT TTTTGGAACA AATGGACCTG TTGACCTGAA AAAAATAACA 
AACTTTTTCA GAGGGGATCG TTGTAGAAGT CTAACTGGAA AACCCAAACT TTTCATTATT 
CAGGTTATTA TTCTTGGCGA AATTCAAAGG ATGGCTCCTG GTTCATCCAG TCGCTTTGTG 
CCATGCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu102834
Clone ID Related Accession (Same CDS sequence) NM_001354783.1
Accession Version NM_001354783.1 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 576bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-11-25
Organism Homo sapiens(human)
Product caspase-3 isoform d
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC079257.7 and AC073932.4. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
301
361
421
481
541
ATGTCTGATG CTTTAATAAA GGTATCCATG GAGAACACTG AAAACTCAGT GGATTCAAAA 
TCCATTAAAA ATTTGGAACC AAAGATCATA CATGGAAGCG AATCAATGGA CTCTGGAATA 
TCCCTGGACA ACAGTTATAA AATGGATTAT CCTGAGATGG GTTTATGTAT AATAATTAAT 
AATAAGAATT TTCATAAAAG CACTGGAATG ACATCTCGGT CTGGTACAGA TGTCGATGCA 
GCAAACCTCA GGGAAACATT CAGAAACTTG AAATATGAAG TCAGGAATAA AAATGATCTT 
ACACGTGAAG AAATTGTGGA ATTGATGCGT GATGTTTCTA AAGAAGATCA CAGCAAAAGG 
AGCAGTTTTG TTTGTGTGCT TCTGAGCCAT GGTGAAGAAG GAATAATTTT TGGAACAAAT 
GGACCTGTTG ACCTGAAAAA AATAACAAAC TTTTTCAGAG GGGATCGTTG TAGAAGTCTA 
ACTGGAAAAC CCAAACTTTT CATTATTCAG GTTATTATTC TTGGCGAAAT TCAAAGGATG 
GCTCCTGGTT CATCCAGTCG CTTTGTGCCA TGCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001341712.1
CDS429..1004
Translation

Target ORF information:

RefSeq Version NM_001354783.1
Organism Homo sapiens(human)
Definition Homo sapiens caspase 3 (CASP3), transcript variant 9, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001354783.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
ATGTCTGATG CTTTAATAAA GGTATCCATG GAGAACACTG AAAACTCAGT GGATTCAAAA 
TCCATTAAAA ATTTGGAACC AAAGATCATA CATGGAAGCG AATCAATGGA CTCTGGAATA 
TCCCTGGACA ACAGTTATAA AATGGATTAT CCTGAGATGG GTTTATGTAT AATAATTAAT 
AATAAGAATT TTCATAAAAG CACTGGAATG ACATCTCGGT CTGGTACAGA TGTCGATGCA 
GCAAACCTCA GGGAAACATT CAGAAACTTG AAATATGAAG TCAGGAATAA AAATGATCTT 
ACACGTGAAG AAATTGTGGA ATTGATGCGT GATGTTTCTA AAGAAGATCA CAGCAAAAGG 
AGCAGTTTTG TTTGTGTGCT TCTGAGCCAT GGTGAAGAAG GAATAATTTT TGGAACAAAT 
GGACCTGTTG ACCTGAAAAA AATAACAAAC TTTTTCAGAG GGGATCGTTG TAGAAGTCTA 
ACTGGAAAAC CCAAACTTTT CATTATTCAG GTTATTATTC TTGGCGAAAT TCAAAGGATG 
GCTCCTGGTT CATCCAGTCG CTTTGTGCCA TGCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu102839
Clone ID Related Accession (Same CDS sequence) NM_001354784.1
Accession Version NM_001354784.1 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 471bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-11-25
Organism Homo sapiens(human)
Product caspase-3 isoform e
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC079257.7 and AC073932.4. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803612.181040.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03267764 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
301
361
421
ATGGACTCTG GAATATCCCT GGACAACAGT TATAAAATGG ATTATCCTGA GATGGGTTTA 
TGTATAATAA TTAATAATAA GAATTTTCAT AAAAGCACTG GAATGACATC TCGGTCTGGT 
ACAGATGTCG ATGCAGCAAA CCTCAGGGAA ACATTCAGAA ACTTGAAATA TGAAGTCAGG 
AATAAAAATG ATCTTACACG TGAAGAAATT GTGGAATTGA TGCGTGATGT TTCTAAAGAA 
GATCACAGCA AAAGGAGCAG TTTTGTTTGT GTGCTTCTGA GCCATGGTGA AGAAGGAATA 
ATTTTTGGAA CAAATGGACC TGTTGACCTG AAAAAAATAA CAAACTTTTT CAGAGGGGAT 
CGTTGTAGAA GTCTAACTGG AAAACCCAAA CTTTTCATTA TTCAGGTTAT TATTCTTGGC 
GAAATTCAAA GGATGGCTCC TGGTTCATCC AGTCGCTTTG TGCCATGCTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001341713.1
CDS171..641
Translation

Target ORF information:

RefSeq Version NM_001354784.1
Organism Homo sapiens(human)
Definition Homo sapiens caspase 3 (CASP3), transcript variant 10, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001354784.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
ATGGACTCTG GAATATCCCT GGACAACAGT TATAAAATGG ATTATCCTGA GATGGGTTTA 
TGTATAATAA TTAATAATAA GAATTTTCAT AAAAGCACTG GAATGACATC TCGGTCTGGT 
ACAGATGTCG ATGCAGCAAA CCTCAGGGAA ACATTCAGAA ACTTGAAATA TGAAGTCAGG 
AATAAAAATG ATCTTACACG TGAAGAAATT GTGGAATTGA TGCGTGATGT TTCTAAAGAA 
GATCACAGCA AAAGGAGCAG TTTTGTTTGT GTGCTTCTGA GCCATGGTGA AGAAGGAATA 
ATTTTTGGAA CAAATGGACC TGTTGACCTG AAAAAAATAA CAAACTTTTT CAGAGGGGAT 
CGTTGTAGAA GTCTAACTGG AAAACCCAAA CTTTTCATTA TTCAGGTTAT TATTCTTGGC 
GAAATTCAAA GGATGGCTCC TGGTTCATCC AGTCGCTTTG TGCCATGCTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

PubMed