Home » Gene Synthesis & Molecular Biology Services » ORF » GenEZ™ Hot genes » TERT gene
Do you need TERT Gene to express the TERT protein for functional or characterization studies? Get the TERT gene in an Expression-Ready Vector for your molecular biology studies by ordering a TERT ORF Clone.
Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity. [provided by RefSeq, Jul 2008]
The human TERT gene is shown in the context of the human genome below. To see information about the TERT gene in other species, please use the Search Tool to select your desired species. GenScript has in-stock ORF clones for mouse TERT, rat TERT, and human TERT, as well as on-demand TERT ORF clones in 183 other species.
GenEZ™ ORF CDNA Clones make it easy to order customized expression-ready ORF clones from the world's largest commercial ORF clone database.