This gene encodes a member of the DNA mismatch repair MutS family. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein heterodimerizes with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene may be associated with hereditary nonpolyposis colon cancer, colorectal cancer, and endometrial cancer. Transcripts variants encoding different isoforms have been described. [provided by RefSeq, Jul 2013]
The human MSH6 gene is shown in the context of the human genome below. To see information about the MSH6 gene in other species, please use the Search Tool to select your desired species. GenScript has in-stock ORF clones for mouse MSH6, rat MSH6, and human MSH6, as well as on-demand MSH6 ORF clones in 183 other species.
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