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NCOR1 (Nuclear receptor corepressor 1) gene, Homo sapiens

Do you need expression-ready NCOR1 Gene to study the functions and characteristics? GenScript offers NCOR1 gene in any custom vector for your molecular biology studies by ordering NCOR1 ORF Clone.

About the NCOR1 gene

NCOR1 encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20.[provided by RefSeq, Jun 2010]

Genomic context of NCOR1 gene

The human NCOR1 gene is shown in the context of the human genome below. To see information about the NCOR1 gene in other species, please use the  Search tool  to select your desired species. GenScript has on-demand NCOR1 ORF clones in other 183 species.

Chromosome 17 - NC_000017.11

Chromosome 17 - NC_000017.11

Genomic sequence of NCOR1 gene

Genomic sequence of NCOR1 gene

Bibliography

1.Autoregulatory loop of nuclear corepressor 1 expression controls invasion, tumor growth, and metastasis. —— Martínez-Iglesias OA, et al. Proc Natl Acad Sci U S A, 2016 Jan 19. PMID 26729869
3.NCoR controls glioblastoma tumor cell characteristics. —— Heldring N, et al. Neuro Oncol, 2014 Jan. PMID 24335696
5.Aberrant nuclear repressor coreceptor 1 localization in human retinoblastoma. —— Nazha B, et al. Ophthalmic Res, 2013. PMID 23295231
See citations in PubMed for homologs of this gene provided by HomoloGene

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